The Mouse Xenograft Model in Cancer Research
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".
Deadline for manuscript submissions: closed (15 July 2024) | Viewed by 1829
Special Issue Editor
Interests: cancer research; anticancer drug development; mouse models of cancer; xenografts; cell culture; natural products; small molecules
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Human-to-mouse cancer xenografts are commonly used in cancer research to study the effectiveness of new treatments and to gain a better understanding of cancer biology.
Xenografts can be made from a wide range of human cancers, including breast, prostate, lung and colon cancers. They can also be used to study the effects of different cancer therapies, such as chemotherapy, radiotherapy and immunotherapy, in a living organism.
The use of human-to-mouse cancer xenografts has become a valuable tool in cancer research because it allows researchers to study human cancer in a living organism in a way that is not possible with cell cultures or other in vitro models.
However, there are limitations to this technique. These models cannot recapitulate the complex interactions between tumour cells, stroma and the human immune system. In addition, the use of animal models raises ethical concerns, and there is an ongoing debate about the validity of using animal models to study human diseases.
In this context, this Special Issue aims to bring the attention of Cancers readers to advances, cutting-edge developments, expertise and know-how across all cancer types in regard to these valuable animal models of cancer. Thus, we cordially invite authors to submit original articles, reviews and opinions that highlight their potential as tools for basic, translational and even precision medicine.
Dr. Konstantinos Dimas
Guest Editor
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Keywords
- xenografts
- patient-derived xenograft models
- humanised mice
- organoids
- tumour biology
- tumour microenvironment
- immunotherapy
- novel anticancer therapies
- new biomarkers
- precision medicine
- gene therapy
- epigenetics
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