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Cancers
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Research of Neurosurgery for Brain Tumors
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Research of Neurosurgery for Brain Tumors

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: closed (23 February 2024) | Viewed by 3598

Special Issue Editor

Dr. Caroline Apra

E-Mail Website
Guest Editor
Neurosurgery Department, Henri Mondor Hospital, Assistance Publique-Hôpitaux de Paris, 94010 Créteil, France
Interests: neurosurgery; neuro-oncology; intracranial tumors; meningiomas; solitary fibrous tumors; perioperative detection; surgical innovation; pedagogy

Special Issue Information

Dear Colleagues,

Brain tumors include a wild range of primary and secondary tumors that remain deadly diseases despite the variety of available treatments in general oncology. Most recent treatments prove inefficient against brain tumors, mostly because of their particular environment, with specific immune components and neural activity, making the transposition of immunotherapy or targeted molecules ineffective, despite direct intrathecal administration. In addition, the invasion of cancerous cells into functional brain parenchyma leads to limited options in terms of local control of the disease while preserving neurological functions.

Neurosurgery remains the first step of diagnosis and treatment, and research in this area remains a key factor in approaching the tumors. Optimizing the oncological and neurological balance during surgery is a daily challenge, even with intraoperative tools allowing a better understanding of the local tissue. The development of animal or simulation models are needed to allow new tools to emerge, young neurosurgeons to practice safely, and brain cancer researchers to deal with realistic models when tackling fundamental mechanistic questions.

For this Special Issue, we invite neurosurgeons, oncologists, engineers, and biologists to submit their articles or reviews. We are particularly interested in new findings or concepts in the areas of research models for brain tumor neurosurgery, surgery simulation, intraoperative tools and techniques, and innovative thinking to approach neuro-onco-surgery and its teaching. Contributions from oncological surgeons dealing with other types of cancer are also of great interest.

Dr. Caroline Apra
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • glioma
  • glioblastoma
  • brain metastases
  • surgical innovation
  • immunotherapy
  • CAR-T cells
  • IDH
  • MGMT
  • brain–blood barrier
  • cancer neuroscience

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

19 pages, 1302 KiB  
Article
Is Carmustine Wafer Implantation in Progressive High-Grade Gliomas a Relevant Therapeutic Option? Complication Rate, Predictors of Complications and Onco-Functional Outcomes in a Series of 53 Cases
by Grigorios Gkasdaris, Julien Berthiller, Jacques Guyotat, Emmanuel Jouanneau, Clémentine Gallet, David Meyronet, Laure Thomas, Stéphanie Cartalat, Antoine Seyve, Jérôme Honnorat, François Ducray and Thiebaud Picart
Cancers 2024, 16(20), 3465; https://doi.org/10.3390/cancers16203465 - 12 Oct 2024
Viewed by 1108
Abstract
Background/Objectives: The aim was to determine the complication rate and the predictors of complications and survival in high-grade glioma surgically managed at progression with implantation of Carmustine wafers. Methods: A retrospective series of 53 consecutive patients operated on between 2017 and [...] Read more.
Background/Objectives: The aim was to determine the complication rate and the predictors of complications and survival in high-grade glioma surgically managed at progression with implantation of Carmustine wafers. Methods: A retrospective series of 53 consecutive patients operated on between 2017 and 2022 was built. Results: The median age was 55 ± 10.9 years. The rates of global and infectious complications were 35.8% and 18.9%, respectively. In multivariate analysis, patients with a preoperative neurological deficit were more prone to develop a postoperative complication (HR = 5.35 95% CI 1.49–19.26, p = 0.01). No predictor of infectious complication was identified. In the grade 4 glioma subgroup (n = 44), progression-free and overall survival (calculated starting from the reresection) reached 3.95 months, 95% CI 2.92–5.21 and 11.51 months, 95% CI 9.11–17.18, respectively. Preoperative KPS > 80% (HR = 0.97 95% CI 0.93–0.99, p = 0.04), Gross Total Resection (HR = 0.38 95% CI 0.18–0.80, p = 0.01), and 3-month postoperative KPS > 80% (HR = 0.35 95% CI 0.17–0.72, p = 0.004) were predictors of prolonged overall survival. Conclusions: Surgical resection is a relevant option in high-grade gliomas at progression, especially in patients with a preoperative KPS > 80%, without preoperative neurological deficit, and amenable to complete resection. In patients elected for surgery, Carmustine wafer implantation is associated with a high rate of complications. It is consequently critical to closely monitor the patients for whom this option is chosen. Full article
(This article belongs to the Special Issue Research of Neurosurgery for Brain Tumors)
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19 pages, 2796 KiB  
Article
Establishment of Different Intraoperative Monitoring and Mapping Techniques and Their Impact on Survival, Extent of Resection, and Clinical Outcome in Patients with High-Grade Gliomas—A Series of 631 Patients in 14 Years
by Franziska Staub-Bartelt, Marian Preetham Suresh Babu, Andrea Szelényi, Marion Rapp and Michael Sabel
Cancers 2024, 16(5), 926; https://doi.org/10.3390/cancers16050926 - 25 Feb 2024
Cited by 2 | Viewed by 1660
Abstract
BACKGROUND: The resection of brain tumors can be critical concerning localization, but is a key point in treating gliomas. Intraoperative neuromonitoring (IONM), awake craniotomy, and mapping procedures have been incorporated over the years. Using these intraoperative techniques, the resection of eloquent-area tumors without [...] Read more.
BACKGROUND: The resection of brain tumors can be critical concerning localization, but is a key point in treating gliomas. Intraoperative neuromonitoring (IONM), awake craniotomy, and mapping procedures have been incorporated over the years. Using these intraoperative techniques, the resection of eloquent-area tumors without increasing postoperative morbidity became possible. This study aims to analyze short-term and particularly long-term outcomes in patients diagnosed with high-grade glioma, who underwent surgical resection under various technical intraoperative settings over 14 years. METHODS: A total of 1010 patients with high-grade glioma that underwent resection between 2004 and 2018 under different monitoring or mapping procedures were screened; 631 were considered eligible for further analyses. We analyzed the type of surgery (resection vs. biopsy) and type of IONM or mapping procedures that were performed. Furthermore, the impact on short-term (The National Institute of Health Stroke Scale, NIHSS; Karnofsky Performance Scale, KPS) and long-term (progression-free survival, PFS; overall survival, OS) outcomes was analyzed. Additionally, the localization, extent of resection (EOR), residual tumor volume (RTV), IDH status, and adjuvant therapy were approached. RESULTS: In 481 patients, surgery, and in 150, biopsies were performed. The number of biopsies decreased significantly with the incorporation of awake surgeries with bipolar stimulation, IONM, and/or monopolar mapping (p < 0.001). PFS and OS were not significantly influenced by any intraoperative technical setting. EOR and RTV achieved under different operative techniques showed no statistical significance (p = 0.404 EOR, p = 0.186 RTV). CONCLUSION: Based on the present analysis using data from 14 years and more than 600 patients, we observed that through the implementation of various monitoring and mapping techniques, a significant decrease in biopsies and an increase in the resection of eloquent tumors was achieved. With that, the operability of eloquent tumors without a negative influence on neurological outcomes is suggested by our data. However, a statistical effect of monitoring and mapping procedures on long-term outcomes such as PFS and OS could not be shown. Full article
(This article belongs to the Special Issue Research of Neurosurgery for Brain Tumors)
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