Special Issue "Understanding the Evolutionary Dynamics and Ecology of Cancer in Treatment Resistance"
Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 9677
Interests: cancer evolution; metastasis; tumor microenvironment; non-cell autonomous interactions
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As the importance of somatic evolution in driving cancer initiation and progression is being increasingly recognized, we are now in a place where we can begin to understand its potential role in treatment. Virtually all advanced tumors become resistant to clinically available treatments. Evolution and ecology are key elements in explaining this resistance: in a sufficiently heterogeneous tumor, certain tumor cells will always avoid the full impact of the treatment. This could be the result of insufficient delivery due to the microenvironment, the cells having a (relative) degree of resistance to said treatment through genetic and epigenetic mechanisms, or as a result of the interactions between tumor cells with cells in the stroma. A better understanding of these factors could help us delay or even prevent the emergence of resistance and, potentially, to steer the evolution of the tumor towards clinically desirable outcomes in a patient-specific manner.
For this Special Issue of Cancers, we invite research articles and focused reviews on all aspects of cancer evolution and ecology related to treatment.
Prof. Dr. David Basanta
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.