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Special Issue "Chronic Intestinal Inflammation and Cancers"
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Epidemiology and Prevention".
Deadline for manuscript submissions: 31 August 2023 | Viewed by 4767
Special Issue Editors
Interests: inflammatory bowel disease; IBD-associated cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
It is well known that inflammation-associated colorectal cancer shows different clinicopathological characteristics compared to sporadic colorectal cancer. These include: a younger age at diagnosis, a worse outcome, and a different molecular pathway (which more frequently includes mutation on the TP53 gene). Moreover, in inflammatory bowel disease, higher frequencies of signet rings and mucinous adenocarcinomas have been suggested. Furthermore, when focusing on precancerous chronic inflammation-associated lesions, it has been shown that these are more frequently non-polypoid in patients with inflammatory bowel diseases and are thus more difficult to detect during screening colonoscopies. Chromoendoscopy, able to enhance polyp detection, currently represents the gold standard technique for colorectal cancer screening in these patients, thus allowing a better characterization of the lesions. A wider application of advanced endoscopic resection techniques is therefore reached by using this technique.
Chronic inflammation leading to small bowel cancer has also been described in the development of cancers complicating coeliac disease and Crohn’s disease. Different molecular pathways and risk factors have been described in these conditions.
The role of immunomodulators in determining the risk of cancer in patients with a prior history of cancer is still debated, particularly in inflammatory bowel disease, in patients often requiring conventional immunosuppressives, or biologic therapies for the underlying chronic intestinal inflammation.
We are pleased to invite you to contribute to the Special Issue “Chronic intestinal inflammation and cancers”.
The aim of the present Special Issue is to summarize current evidences and possibly to increase knowledge in the field of intestinal cancers associated with chronic inflammation. We aim to report and to investigate evidences regarding inflammation-associated intestinal cancers from its precursors to patient’s outcome. For this purpose, we will collect at least 10 articles. The Special Issue may be printed in book form if this number is reached.
This Special Issue aims to deepen knowledge in the field of intestinal cancers associated with chronic inflammation.
Accepted article types are original articles and reviews.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:
- Intestinal cancers associated with chronic inflammation and outcome;
- Intestinal cancer associated with chronic inflammation: molecular pathway;
- Colorectal cancer associated with chronic inflammation and cancer precursors: diagnosis and management;
- Immunomodulators in patients with a prior history of cancer;
- Intestinal cancers associated with chronic inflammation: epidemiology and histological characterization;
- Colorectal cancer and small bowel cancer in Inflammatory Bowel Disease;
- Small intestinal cancer and coeliac disease.
We look forward to receiving your contributions.
Dr. Livia Biancone
Prof. Dr. David Laharie
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- colorectal cancer
- chronic inflammation
- inflammatory bowel disease
- inflammation-associated dysplasia
- cancer molecular pathways