Topic Editors

Prof. Dr. Shenglin Huang
1. Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China
2. Shanghai Cancer Center, Fudan University, Shanghai 200032, China
Department of Obstetrics and Gynaecology, The Ohio State University Wexner Medical Center, Columbus, OH, USA
Dr. Jialei Wang
1. Department of Thoracic Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China
2. Institute of Thoracic Oncology, Fudan University, Shanghai 200032, China

Extracellular Vesicles in Cancer Diagnosis and Treatment

Abstract submission deadline
20 May 2024
Manuscript submission deadline
20 July 2024
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6543

Topic Information

Dear Colleagues,

Extracellular vesicles (EVs) are specialized membranous, nanosized endocytic vesicles that are secreted by most cell types in the human body, including tumor cells. EVs contain key biomolecules such as RNA, DNA, proteins, and lipids, which are promising biomarkers for clinical applications in cancer management. This Topic aims to contribute original articles and reviews to the investigation and identification of EV-related biomarkers for cancer diagnosis and treatment.

Prof. Dr. Shenglin Huang
Dr. Linlin Guo
Dr. Jialei Wang
Topic Editors

Keywords

  • extracellular vesicles
  • cancer diagnosis
  • cancer treatment
  • mRNA
  • lncRNA
  • circRNA
  • protein
  • DNA
  • biomarker

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Biomolecules
biomolecules
5.5 8.3 2011 16.9 Days CHF 2700 Submit
Cancers
cancers
5.2 7.4 2009 17.9 Days CHF 2900 Submit
Current Oncology
curroncol
2.6 2.6 1994 18 Days CHF 2200 Submit
Journal of Clinical Medicine
jcm
3.9 5.4 2012 17.9 Days CHF 2600 Submit
Onco
onco
- - 2021 18.3 Days CHF 1000 Submit

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Published Papers (2 papers)

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22 pages, 1643 KiB  
Review
Plant-Derived Extracellular Vesicles and Their Exciting Potential as the Future of Next-Generation Drug Delivery
by Faisal A. Alzahrani, Mohammad Imran Khan, Nader Kameli, Elham Alsahafi and Yasir Mohamed Riza
Biomolecules 2023, 13(5), 839; https://doi.org/10.3390/biom13050839 - 15 May 2023
Cited by 13 | Viewed by 4124
Abstract
Plant cells release tiny membranous vesicles called extracellular vesicles (EVs), which are rich in lipids, proteins, nucleic acids, and pharmacologically active compounds. These plant-derived EVs (PDEVs) are safe and easily extractable and have been shown to have therapeutic effects against inflammation, cancer, bacteria, [...] Read more.
Plant cells release tiny membranous vesicles called extracellular vesicles (EVs), which are rich in lipids, proteins, nucleic acids, and pharmacologically active compounds. These plant-derived EVs (PDEVs) are safe and easily extractable and have been shown to have therapeutic effects against inflammation, cancer, bacteria, and aging. They have shown promise in preventing or treating colitis, cancer, alcoholic liver disease, and even COVID-19. PDEVs can also be used as natural carriers for small-molecule drugs and nucleic acids through various administration routes such as oral, transdermal, or injection. The unique advantages of PDEVs make them highly competitive in clinical applications and preventive healthcare products in the future. This review covers the latest methods for isolating and characterizing PDEVs, their applications in disease prevention and treatment, and their potential as a new drug carrier, with special attention to their commercial viability and toxicological profile, as the future of nanomedicine therapeutics. This review champions the formation of a new task force specializing in PDEVs to address a global need for rigor and standardization in PDEV research. Full article
(This article belongs to the Topic Extracellular Vesicles in Cancer Diagnosis and Treatment)
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18 pages, 2599 KiB  
Review
Exosomal LncRNAs in Gastrointestinal Cancer: Biological Functions and Emerging Clinical Applications
by Yuntong Sun, Fengtian Sun, Jianhua Jin, Wenrong Xu and Hui Qian
Cancers 2023, 15(3), 959; https://doi.org/10.3390/cancers15030959 - 02 Feb 2023
Cited by 4 | Viewed by 1629
Abstract
Due to the lack of specific and effective biomarkers and therapeutic targets, the early diagnosis and treatment of gastrointestinal cancer remain unsatisfactory. As a type of nanosized vesicles derived from living cells, exosomes mediate cell-to-cell communication by transporting bioactive molecules, thus participating in [...] Read more.
Due to the lack of specific and effective biomarkers and therapeutic targets, the early diagnosis and treatment of gastrointestinal cancer remain unsatisfactory. As a type of nanosized vesicles derived from living cells, exosomes mediate cell-to-cell communication by transporting bioactive molecules, thus participating in the regulation of many pathophysiological processes. Recent evidence has revealed that several long non-coding RNAs (lncRNAs) are enriched in exosomes. Exosomes-mediated lncRNAs delivery is critically involved in various aspects of gastrointestinal cancer progression, such as tumor proliferation, metastasis, angiogenesis, stemness, immune microenvironment, and drug resistance. Exosomal lncRNAs represent promising candidates to act as the diagnosis biomarkers and anti-tumor targets. This review introduces the major characteristics of exosomes and lncRNAs and describes the biological functions of exosomal lncRNAs in gastrointestinal cancer development. The preclinical studies on using exosomal lncRNAs to monitor and treat gastrointestinal cancer are also discussed, and the opportunities and challenges for translating them into clinical practice are evaluated. Full article
(This article belongs to the Topic Extracellular Vesicles in Cancer Diagnosis and Treatment)
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