Metabolism of Cancer Cells

Dear Colleagues,

A deeper understanding of the biology of therapy resistance is important for the development of optimal strategies to attain complete cures for cancer. Cancer stem cells (CSC) are the major cause of therapy resistance, being associated with metastasis and constituting the cause of disease relapse. Normal somatic stem cells (SSC) and CSC share many common features, thereby complicating the safe elimination of CSC. Both SSC and CSC have the capacity to self-renew and differentiate, exist in different states (i.e., quiescent versus activated), and are plastic (i.e., can cycle between the different states). A Smorgasbord is defined as a mixture of many different hot and cold dishes that are arranged so that one can serve oneself as much as is desired in a buffet style. It is now clear that both normal stem cells and CSC can sample many different “dishes” at the Smorgasbord table to suit their “behaviors” and “lifestyles” by matching their metabolic needs. Limiting the ability of CSC to pick and choose their food from the “Smorgasbord table” may thereby provide a mechanism for preventing therapy resistance. This Special Issue will focus on the “dietary habits” of cancer cells and CSC in an effort to determine how we may be able to therapeutically exploit this knowledge.

Prof. Dr. Michael Kahn
Dr. Xiaohui Hu
Guest Editors

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• cancer cells
• metabolism
• cancer stem cells
• quiescence
• therapy resistance
• glycolysis
• fatty acid oxidation
• OXPHOS