Impact of Surgery on Brain Cancer and Other Central Nervous System Tumors

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 2039

Special Issue Editors


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1. Radiation Oncology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Viale Bracci, 16-53100 Siena, Italy
2. Department of Biology, College of Science and Technology, Temple University, Philadelphia, PA, USA
Interests: brain tumors; stereotactic radiosurgery; radiobiology; combined treatments; gliomas; brain metastases; molecular markers
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Department of Radiotherapy, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy
Interests: radiotherapy; radio-resistance; rhabdomyosarcoma; adult cancers; epigenetic drugs; targeted therapy; ERK functions; MYC
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Department of Radiological Sciences, Oncology and Anatomical Pathology, Division of Radiotherapy, Sapienza University of Rome, 00161 Rome, Italy
Interests: brain tumors; brain metastases; glioblastoma; radiotherapy; radiosurgery
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Special Issue Information

Dear Colleagues,

In CNS oncological disease, surgery plays a key role in the treatment. Modern neurosurgery has allowed a broadening of resectability criteria by improving both extension and postoperative side effects. However, radical surgery is not always possible given the treatment site. This Special Issue would like to take stock of the impact of surgical treatment in clinical terms.

We hope to stimulate scientific attention on a delicate and highly impacting aspect in determining the clinical outcome of patients with brain and CNS neoplasms, such as surgical extension, which is a point that has still not been clarified in various oncological pathologies of the central nervous system. We believe it is necessary to develop a Special Issue to collect works focused on the impact and role of surgery in different oncological diseases in CNS. We look forward to your contributions.

Dr. Paolo Tini
Dr. Francesco Marampon
Dr. Giuseppe Minniti
Guest Editors

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Keywords

  • glioblastoma
  • low-grade gliomas
  • ependymomas
  • PNET
  • meningiomas
  • medulloblastomas
  • other brain tumors

Published Papers (1 paper)

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Review

19 pages, 3826 KiB  
Review
Interdisciplinary Therapeutic Approaches to Atypical and Malignant Meningiomas
by Leonidas Trakolis and Athanasios K. Petridis
Cancers 2023, 15(17), 4251; https://doi.org/10.3390/cancers15174251 - 25 Aug 2023
Cited by 2 | Viewed by 1614
Abstract
Meningiomas have the highest incidence among brain tumors. In contrast to benign tumors that constitute the majority of this tumor entity, the treatment of aggressive meningiomas (WHO Grade 2 and 3) is more challenging, requiring gross total removal of the tumor and the [...] Read more.
Meningiomas have the highest incidence among brain tumors. In contrast to benign tumors that constitute the majority of this tumor entity, the treatment of aggressive meningiomas (WHO Grade 2 and 3) is more challenging, requiring gross total removal of the tumor and the affected dura and adjuvant radiotherapy. Sometimes the location and/or the configuration of the tumor do not favor radical surgical resection without endangering the patient’s clinical condition after surgery and pharmacological therapy has, until now, not been proven to be a reliable alternative. Discussion: In this narrative review, we discuss the current literature with respect to the management of meningiomas, discussing the importance of the grade of resection in the overall prognosis of the patient and in the planning of adjuvant therapy. Conclusions: According to the location and size of the tumor, radical resection should be taken into consideration. In patients with aggressive meningiomas, adjuvant radiotherapy should be performed after surgery. In cases of skull base meningiomas, a maximal, though safe, resection should take place before adjuvant therapy. An interdisciplinary approach is beneficial for patients with primary or recurrent meningioma. Full article
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