Special Issue "Sex Differences in the Healthy and Diseased Brain"
A special issue of Brain Sciences (ISSN 2076-3425).
Deadline for manuscript submissions: closed (30 June 2018)
In 2015, the National Institutes of Health (NIH) mandated the inclusion of both sexes in most research with animals, tissues or cells. This is a welcomed development, as robust sex differences in the anatomy, physiology, and biochemistry of the healthy brain are likely to underlie the inherent sex bias in the diseased brain. For instance, females suffer more from mood disorders, such as depression and anxiety, whereas males are more susceptible to Parkinson's disease (PD), attention-deficit hyperactivity disorder (ADHD), autism, and early-onset schizophrenia. Hence, better understanding of the biology underlying brain sex differences will be vital for designing novel therapeutic agents that will have optimal effectiveness in each sex.
It is well established that many sex differences in both the development and course of neuropsychiatric and neurodegenerative disorders are attributable to sex steroids, in particular, the neuroprotective actions of the sex hormone, estradiol (R.Hill, Neuroscience and Biobehavioural Reviews 2016). However, emerging evidence indicates that the sex chromosome genes (i.e. X- and Y-linked genes) also contribute to sex differences in the health and diseased brain (Lee and Harley, 2012, Bioessays). Taken together, these studies highlight the importance of understanding the interplay between sex hormones and sex-specific genes in healthy and diseased brain.
This Special Issue, covering the influence of sex on brain structure and function in both animals and humans, will discuss the interplay between sex hormones and sex-chromosome genes in regulating brain development and function in both health and disease.
Dr. Joohyung Lee
Dr. Rachel Hill
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 650 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Brain Sex Differences
- Sex hormones
- Sex chromosomes
- Neurodegenerative disorders
- Neuropsychiatric disorders