Special Issue "Neurodegeneration in Developmental and Neoplastic Disorders of the Nervous System"
A special issue of Brain Sciences (ISSN 2076-3425).
Deadline for manuscript submissions: closed (30 June 2016)
Assoc. Prof. Dr. Basavaraj S. Balapal
Department of Psychiatry, New York University Langone Medical Center, New York City, New York, USA
Faculty at Columbia University Medical Center, Scientist, Division of Analytical Psychopharmacology, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York, USA
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Interests: cannabinoid receptors; synaptic plasticity; learning and memory; developmental disorders; neurodegeneration; drugs of abuse and psychiatric disorders
The mechanisms which direct the important stages of brain development to orchestrate functional synaptic structure are gradually being elucidated. However, the mechanisms that regulate synaptic stability and neuronal loss that result in lifelong neurobehavioral outcome are not well known. Synapse loss is an early and invariant characteristic of many neurodegenerative diseases and in many cases the level of synapse loss correlates with the severity of the disease. The gestational and postnatal developments are appearing to be particularly vital for making stable neuronal connections that shape a lifetime of experience. The influence of environmental factors including drugs of abuse, exposure to toxicants, diet, and stress during gestation or early to late postnatal development have the ability to alter brain development and synaptic plasticity, resulting in lifelong intellectual disability and cognitive deficits. Hence, understanding the neurobehavioral mechanisms that underlie neurodegeneration and synaptic plasticity is crucial to understand the potential targets that will allow the development of therapies to protect synapses and improve neurobehavioral outcome.
The current Special Issue is aimed to collect a selected number of articles that demonstrate deeper insight in these topics, which bring both sound scientific and public health impacts.
Dr. Balapal S. Basavarajappa
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 850 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Drugs of abuse
- Environmental toxicants
- Molecular mechanisms
- Early brain development
- Synaptic plasticity
- Intellectual disability
- Cognitive deficits
- Learning and memory