Special Issue "The Function of Microglia in Neurodegenerative Diseases"

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurodegenerative Diseases".

Deadline for manuscript submissions: 30 October 2021.

Special Issue Editors

Dr. Helene Hirbec
E-Mail Website
Guest Editor
Institute for Functional Genomics (IGF), University of Montpellier, CNRS, INSERM, Montpellier, France
Interests: immunohistochemistry; neurodegenerative diseases; microglia; nmda receptor; synaptosomes; microglial activation
Prof. Dr. Florence E. Perrin
E-Mail Website
Guest Editor
INSERM, Institut Universitaire de France, University of Montpellier, Montpellier, France
Interests: transcriptomics; spinal cord injury; immunohistochemistry; neuron; MRI; motor behaviour; neuroinflammation; microglia; spinal cord

Special Issue Information

Dear Colleagues,

Microglia play key roles in central nervous system (CNS) disorders, including neurodegenerative diseases, neurotraumatic disorders, psychiatric pathologies, pathological pain, and CNS tumors. Although dysregulation of microglial functions is a shared and key feature in neurological disorders, we are just beginning to decrypt the disparity of microglial responses in CNS pathologies. 

In this Special Issue, we welcome studies focusing on:

  • The role of microglia in neurodegenerative diseases including amyotrophic lateral sclerosis, Alzheimer’s disease, Huntington’s disease, multiple sclerosis, and Parkinson’s disease;
  • The role of microglia in neurotraumatic disorders including spinal cord and brain injuries;
  • The role of microglia in psychiatric disease;
  • The role of microglia in pathological pain;
  • The role of microglia in CNS tumors;
  • The targeting of microglia function as a therapeutic strategy. 

We invite original research and review articles integrating basic and/or translational research reporting positive (but also negative) findings that reveal the roles of microglial cells in neuropathogenesis. Technical papers aimed at assessing microglia reaction are also welcomed. 

Dr. Helene Hirbec
Dr. Florence E. Perrin
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Microglia
  • Neuroinflammation
  • Neurodegenerative diseases
  • Neurotraumatic injuries
  • CNS tumors

Published Papers (1 paper)

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Research

Article
A Core Transcription Regulatory Circuitry Defining Microglia Cell Identity Inferred from the Reanalysis of Multiple Human Microglia Differentiation Protocols
Brain Sci. 2021, 11(10), 1338; https://doi.org/10.3390/brainsci11101338 - 11 Oct 2021
Viewed by 379
Abstract
Microglia, the immune cells in the brain involved in both homeostasis and injury/infection control, play a predominant role in neurodegenerative diseases. In vivo studies on microglia are limited due to the requirement of surgical intervention, which can lead to the destruction of the [...] Read more.
Microglia, the immune cells in the brain involved in both homeostasis and injury/infection control, play a predominant role in neurodegenerative diseases. In vivo studies on microglia are limited due to the requirement of surgical intervention, which can lead to the destruction of the tissues. Over the last few years, multiple protocols—presenting a variety of strategies—have described microglia differentiation issued from human pluripotent stem cells. Herein, we have reanalyzed the transcriptomes released on six different microglia differentiation protocols and revealed a consensus core of master transcription regulatory circuitry defining microglia identity. Furthermore, we have discussed the major divergencies among the studied protocols and have provided suggestions to further enhance microglia differentiation assays. Full article
(This article belongs to the Special Issue The Function of Microglia in Neurodegenerative Diseases)
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