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Article

A Core Transcription Regulatory Circuitry Defining Microglia Cell Identity Inferred from the Reanalysis of Multiple Human Microglia Differentiation Protocols

Génomique Métabolique, Genoscope, Institut François Jacob, CEA, CNRS, Univ Evry, Université Paris-Saclay, 91057 Evry, France
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Academic Editors: Helene Hirbec and Florence E. Perrin
Brain Sci. 2021, 11(10), 1338; https://doi.org/10.3390/brainsci11101338
Received: 13 September 2021 / Revised: 28 September 2021 / Accepted: 4 October 2021 / Published: 11 October 2021
(This article belongs to the Special Issue The Function of Microglia in Neurodegenerative Diseases)
Microglia, the immune cells in the brain involved in both homeostasis and injury/infection control, play a predominant role in neurodegenerative diseases. In vivo studies on microglia are limited due to the requirement of surgical intervention, which can lead to the destruction of the tissues. Over the last few years, multiple protocols—presenting a variety of strategies—have described microglia differentiation issued from human pluripotent stem cells. Herein, we have reanalyzed the transcriptomes released on six different microglia differentiation protocols and revealed a consensus core of master transcription regulatory circuitry defining microglia identity. Furthermore, we have discussed the major divergencies among the studied protocols and have provided suggestions to further enhance microglia differentiation assays. View Full-Text
Keywords: microglia differentiation; transcriptomics; gene regulatory networks; systems biology microglia differentiation; transcriptomics; gene regulatory networks; systems biology
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MDPI and ACS Style

Aubert, A.; Stüder, F.; Colombo, B.M.; Mendoza-Parra, M.A. A Core Transcription Regulatory Circuitry Defining Microglia Cell Identity Inferred from the Reanalysis of Multiple Human Microglia Differentiation Protocols. Brain Sci. 2021, 11, 1338. https://doi.org/10.3390/brainsci11101338

AMA Style

Aubert A, Stüder F, Colombo BM, Mendoza-Parra MA. A Core Transcription Regulatory Circuitry Defining Microglia Cell Identity Inferred from the Reanalysis of Multiple Human Microglia Differentiation Protocols. Brain Sciences. 2021; 11(10):1338. https://doi.org/10.3390/brainsci11101338

Chicago/Turabian Style

Aubert, Antoine, François Stüder, Bruno Maria Colombo, and Marco Antonio Mendoza-Parra. 2021. "A Core Transcription Regulatory Circuitry Defining Microglia Cell Identity Inferred from the Reanalysis of Multiple Human Microglia Differentiation Protocols" Brain Sciences 11, no. 10: 1338. https://doi.org/10.3390/brainsci11101338

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