Toxic Mechanisms and Emerging Therapeutic Strategies in Brain Disorders

Dear Colleagues,

Disorders impacting the nervous system often involve complex and multifactorial toxic mechanisms, including oxidative stress, mitochondrial dysfunction, excitotoxicity, protein aggregation, and neuroinflammation. These pathological processes contribute to neuronal damage and progression across a wide spectrum of neurological, neurodegenerative, and neurometabolic diseases. Understanding these toxic cascades is essential for identifying new therapeutic targets and improving clinical outcomes. This Special Issue aims to highlight recent advances in the characterization of neurotoxic mechanisms and to explore innovative therapeutic strategies, including pharmacological, gene-based, and metabolic interventions. We invite original research articles, reviews, and perspectives addressing molecular and cellular pathways of toxicity, biomarker development, and translational approaches for treatment. By bringing together cutting-edge studies from diverse neurological conditions, this issue seeks to foster a deeper understanding of shared mechanisms and promote the development of cross-cutting therapeutic strategies for disorders of the nervous system.

Dr. Alexandra Susana Latini
Dr. Ana Lucia De Paul
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.