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Systematic Review

Blood Biomarkers in Frontotemporal Dementia: Review and Meta-Analysis

1
Department of Neurology, Evangelismos Hospital, 10676 Athens, Greece
2
2nd Department of Neurology, School of Medicine, “Attikon” University General Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece
3
Department of Neurosurgery, School of Medicine, Evangelismos Hospital, National and Kapodistrian University of Athens, 10676 Athens, Greece
4
Ward of Cognitive and Movement Disorders, 1st Department of Neurology, School of Medicine, Eginition Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece
5
Unit of Neurochemistry and Biological Markers, Department of Neurology, School of Medicine, Eginition Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece
*
Author to whom correspondence should be addressed.
Both equally contributed to the preparation of the present article.
Academic Editor: Manuel Menéndez González
Brain Sci. 2021, 11(2), 244; https://doi.org/10.3390/brainsci11020244
Received: 14 January 2021 / Revised: 7 February 2021 / Accepted: 9 February 2021 / Published: 15 February 2021
(This article belongs to the Special Issue Cerebrospinal Fluid Biomarkers in Dementia Disorders)
Biomarkers in cerebrospinal fluid (CSF) are useful in the differential diagnosis between frontotemporal dementia (FTD) and Alzheimer’s dementia (AD), but require lumbar puncture, which is a moderately invasive procedure that can cause anxiety to patients. Gradually, the measurement of blood biomarkers has been attracting great interest. Testing blood instead of CSF, in order to measure biomarkers, offers numerous advantages because it negates the need for lumbar puncture, it is widely available, and can be repeated, allowing the prediction of disease course. In this study, a systematic review of the existing literature was conducted, as well as meta-analysis with greater emphasis on the most studied biomarkers, p-tau and progranulin. The goal was to give prominence to evidence regarding the use of plasma biomarkers in clinical practice. View Full-Text
Keywords: blood biomarkers; frontotemporal dementia; progranulin blood biomarkers; frontotemporal dementia; progranulin
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MDPI and ACS Style

Ntymenou, S.; Tsantzali, I.; Kalamatianos, T.; Voumvourakis, K.I.; Kapaki, E.; Tsivgoulis, G.; Stranjalis, G.; Paraskevas, G.P. Blood Biomarkers in Frontotemporal Dementia: Review and Meta-Analysis. Brain Sci. 2021, 11, 244. https://doi.org/10.3390/brainsci11020244

AMA Style

Ntymenou S, Tsantzali I, Kalamatianos T, Voumvourakis KI, Kapaki E, Tsivgoulis G, Stranjalis G, Paraskevas GP. Blood Biomarkers in Frontotemporal Dementia: Review and Meta-Analysis. Brain Sciences. 2021; 11(2):244. https://doi.org/10.3390/brainsci11020244

Chicago/Turabian Style

Ntymenou, Sofia, Ioanna Tsantzali, Theodosis Kalamatianos, Konstantinos I. Voumvourakis, Elisabeth Kapaki, Georgios Tsivgoulis, George Stranjalis, and George P. Paraskevas. 2021. "Blood Biomarkers in Frontotemporal Dementia: Review and Meta-Analysis" Brain Sciences 11, no. 2: 244. https://doi.org/10.3390/brainsci11020244

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