Biomarkers in Dementia Disorders
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Neurobiology and Clinical Neuroscience".
Deadline for manuscript submissions: closed (31 July 2024) | Viewed by 9348
Special Issue Editors
Interests: dementia; neurodegenerative disorders; Alzheimer’s disease; Lewy body synucle-inopathies; frontotemporal lobar degenerations; tauopathies; TDP43 proteinopa-thies; vascular cognitive impairment; cerebrospinal fluid biomarkers; neurochem-istry; neuropsychology; neuroimaging
Special Issues, Collections and Topics in MDPI journals
Interests: progressive supranuclear palsy; multiple system atrophy; corticobasal syndrome; CSF biomarkers; MRI
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Alzheimer’s disease, the most common type of neurodegenerative dementia, is characterized by two main pathological features: extracellular accumulation of amyloid beta peptides in the form of amyloid plaques and hyperphosphorylation of tau protein, which polymerizes in the form of paired helical filaments, the key component of intraneuronal neurofibrillary tangles. Most frontotemporal lobar degenerations are due to tau or TDP-43 pathology, while a small percentage is due to FUS or more rare pathologies. Parkinson’s disease with or without dementia and dementia with Lewy bodies belong to the group of synucleinopathies. Thus, neurodegenerative dementia disorders are currently viewed as proteinopathies, being characterized by the aggregation (and probably prion-like spread) of one or more protein(s) or peptides. Some of these proteins can be quantified in the CSF or plasma (and probably other fluids as well) and serve not only as biomarkers of various biochemical processes but also as important diagnostic tools. The accumulation of amyloid beta peptides and/or tau in the brain can also be studied with positron emission tomography. Fluid or imaging biomarkers may also be helpful in the diagnosis of secondary causes of dementia, such as autoimmune encephalitis and normal pressure hydrocephalus.
This upcoming Special Issue will highlight the latest advances in fluid and imaging biomarkers for dementia disorders. Original articles, reviews and case reports are all welcome.
Dr. George P. Paraskevas
Dr. Vasilios C. Constantinides
Guest Editors
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Keywords
- dementia
- biomarkers
- cerebrospinal fluid
- plasma
- neuroimaging
- positron emission tomography
- tau
- phospho-tau
- amyloid-beta
- alpha synuclein
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