Speech Loss from Dementia? Understanding Aphasia

Dear Colleagues,

Speech disorders and aphasia are commonly documented in degenerative brain diseases. Their finding has clinical relevance under a diagnostic point of view (as for example in frontotemporal dementias- FTD) and also as predictor of disease progression, as for the progression from Subjective Cognitive Decline to Mild Cognitive Impairment to Dementia.

Language pathology in dementias also offers the opportunity to implement models of normal language, providing information complementary to that derived from stroke.

The extension of the atrophy that progressively encompasses both gray and white matter in parallel with the progressive decay of the various levels of linguistic organization, allows the various neural substrates to be correlated with specific linguistic sub-components, especially in terms of networks.

In the last decades, psycholinguistic, neurolinguistic and computational analyses of language in dementia have been joined by increasingly sophisticated investigation techniques, principally of structural and functional neuroimaging, capable of defining the relationship between brain and language in ever greater detail, not only in terms of localization, but also of distribution and organization of neural networks.

This special issue of Brain Sciences is devoted to studies on language in dementia that may yield advancement in the understanding of normal and pathological language.

Prof. Dr. Maria Caterina Silveri
Dr. Davide Quaranta
Dr. Sonia Di Tella
Guest Editors

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