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New Challenges in the Study of Cognitive Impairment in Parkinson’s...
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New Challenges in the Study of Cognitive Impairment in Parkinson’s Disease

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurodegenerative Diseases".

Deadline for manuscript submissions: 16 June 2025 | Viewed by 3551

Special Issue Editors

Dr. Sonia Di Tella

E-Mail Website
Guest Editor
Department of Psychology, Università Cattolica del Sacro, 20123 Milan, Italy
Interests: Parkinson’s disease; executive functions; language; structural and functional neuroimaging; emotional processing
Special Issues, Collections and Topics in MDPI journals
Dr. Laura Colautti

E-Mail Website
Guest Editor
Department of Psychology, Università Cattolica del Sacro, 20123 Milan, Italy
Interests: Parkinson’s disease; cognition; assessment; rehabilitation; executive functions; learning; decision making; creativity; cognitive reserve

Special Issue Information

Dear Colleagues,

This Special Issue aims to collect the latest findings in the field of cognitive impairments in Parkinson’s disease (PD), focusing on the early detection of symptoms, the influence of individual differences, new therapeutic directions, and how technology and artificial intelligence can support the diagnostic process and the management of cognitive symptoms.

We invite papers that delve into the following:

  • The early detection of the onset of cognitive impairments and a better understanding of the underlying mechanisms;
  • A better understanding of the protective role played by individual differences and other factors (such as reserve mechanisms and creativity);
  • Innovative pharmacological and non-pharmacological approaches;
  • How technology and artificial intelligence can contribute to the early detection and management of cognitive symptoms.

Multidisciplinary approaches are encouraged.

Dr. Sonia Di Tella
Dr. Laura Colautti
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Parkinson’s disease
  • cognitive impairment
  • assessment
  • intervention
  • executive functions
  • learning
  • decision making
  • creativity
  • cognitive reserve

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Published Papers (2 papers)

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15 pages, 1156 KiB  
Article
The Contribution of Cognitive Control Networks in Word Selection Processing in Parkinson’s Disease: Novel Insights from a Functional Connectivity Study
by Sonia Di Tella, Matteo De Marco, Isabella Anzuino, Davide Quaranta, Francesca Baglio and Maria Caterina Silveri
Brain Sci. 2024, 14(9), 913; https://doi.org/10.3390/brainsci14090913 - 11 Sep 2024
Viewed by 1146
Abstract
Parkinson’s disease (PD) patients are impaired in word production when the word has to be selected among competing alternatives requiring higher attentional resources. In PD, word selection processes are correlated with the structural integrity of the inferior frontal gyrus, which is critical for [...] Read more.
Parkinson’s disease (PD) patients are impaired in word production when the word has to be selected among competing alternatives requiring higher attentional resources. In PD, word selection processes are correlated with the structural integrity of the inferior frontal gyrus, which is critical for response selection, and the uncinate fasciculus, which is necessary for processing lexical information. In early PD, we investigated the role of the main cognitive large-scale networks, namely the salience network (SN), the central executive networks (CENs), and the default mode network (DMN), in word selection. Eighteen PD patients and sixteen healthy controls were required to derive nouns from verbs or generate verbs from nouns. Participants also underwent a resting-state functional MRI. Functional connectivity (FC) was examined using independent component analysis. Functional seeds for the SN, CENs, and DMN were defined as spheres, centered at the local activation maximum. Correlations were calculated between the FC of each functional seed and word production. A significant association between SN connectivity and task performance and, with less evidence, between CEN connectivity and the task requiring selection among a larger number of competitors, emerged in the PD group. These findings suggest the involvement of the SN and CEN in word selection in early PD, supporting the hypothesis of impaired executive control. Full article
(This article belongs to the Special Issue New Challenges in the Study of Cognitive Impairment in Parkinson’s Disease)
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34 pages, 1305 KiB  
Systematic Review
Identification of Cognitive Training for Individuals with Parkinson’s Disease: A Systematic Review
by Marina Francesca Gattoni, Silvia Gobbo, Sarah Feroldi, Anna Salvatore, Jorge Navarro, Sandro Sorbi and Francesca Lea Saibene
Brain Sci. 2025, 15(1), 61; https://doi.org/10.3390/brainsci15010061 - 11 Jan 2025
Viewed by 1654
Abstract
Background/Objectives: Parkinson’s disease (PD) is a neurodegenerative disorder, characterised by cardinal motor features and a multitude of non-motor manifestations. Among them, cognitive impairment in PD has been recognised as a defined clinical entity, and it might lead to an increased risk of [...] Read more.
Background/Objectives: Parkinson’s disease (PD) is a neurodegenerative disorder, characterised by cardinal motor features and a multitude of non-motor manifestations. Among them, cognitive impairment in PD has been recognised as a defined clinical entity, and it might lead to an increased risk of developing dementia. Consequently, the present review aimed to ascertain the available interventions for the training of cognitive abilities in persons with PD (PwPD). Methods: PRISMA guidelines were followed to select studies in the following databases: PubMed, PsycINFO, and Web of Science. Two independent reviewers conducted the different phases of the review, and a third expert was called in to address any doubts/conflicts. Randomised controlled trials and randomised clinical trials concerning cognitive training with cognitive outcomes in PwPD were selected. Results: A total of 28 articles were included. The considered studies applied various experimental interventions for the training of cognitive functions in PwPD: computer-based platforms, exergames, paper-and-pencil programmes, dual-task or treadmill training with action observation therapy, motor imagery, and virtual reality components, interventions targeting precise cognitive domain, tele-rehabilitation, transcranial direct current stimulation, structured cognitive training, and multimodal treatments. Cognitive functions were assessed employing neuropsychological tests, self-report questionnaires, and computerised batteries. Conclusions: Overall, the review reported better performances in the experimental groups compared to the control groups, in several cognitive domains. Structured cognitive training emerged as the most effective strategy to enhance cognitive functioning in PwPD. However, further studies are necessary to determine the most appropriate and useful training and to develop interventions that also consider patients’ quality of life. Full article
(This article belongs to the Special Issue New Challenges in the Study of Cognitive Impairment in Parkinson’s Disease)
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