The Future of Psychological Treatments: Precision Approaches and Emerging Methods

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neuropsychiatry".

Deadline for manuscript submissions: 28 March 2027 | Viewed by 578

Editors


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Guest Editor
Clinical and Affective Neuroscience Lab – Cli.A.N., Department of Education, Psychology and Communication Sciences, University of Bari, 70121 Bari, Italy
Interests: affective and clinical neuroscience; emotions; decision-making; experimental psychopathology

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Guest Editor
Department of Education, Psychology and Communication Sciences, University of Bari, 70121 Bari, Italy
Interests: cognitive neuroscience; neuropsychology; brain stimulation; biological psychiatry

Special Issue Information

Dear Colleagues,

Psychological treatments including but not limited to psychotherapy remain one of the most effective and enduring interventions for psychopathological disorders, with robust evidence across mood, anxiety, trauma-related, and personality disorders. However, contemporary psychology care increasingly faces fragmentation between symptom-based nosology, inability to predict relapse, choice of intervention, and the need for more individualized psychological treatment pathways.

This Special Issue aims to provide a state-of-the-art overview of psychotherapy as a core component of modern psychology, emphasizing neuroimaging biomarkers, neural models, clinical effectiveness, mechanistic understanding, and future innovations. We welcome contributions that integrate clinical psychology with psychotherapy research, including translational frameworks that connect cognitive–affective processes to symptom change, treatment failures and functional recovery.

In particular, we encourage work leveraging emerging methods such as computational neuroscience, machine learning-based treatment stratification, digital phenotyping, ecological momentary assessment, neuroimaging-informed psychotherapy, and process-based approaches to psychological change. Novel trial designs (e.g., adaptive interventions, precision psychotherapy, and mechanism-focused RCTs) are also strongly encouraged.

We invite original research, systematic reviews, meta-analyses, brief reports, and theoretical perspectives on psychotherapy mechanisms, biomarkers of treatment response, transdiagnostic interventions, combined treatments, and implementation in real-world clinical settings—ultimately advancing translational applications that improve therapeutic outcomes and personalized care.

Prof. Dr. Alessandro Grecucci
Prof. Dr. Irene Messina
Dr. Davide Rivolta
Guest Editors

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Keywords

  • psychotherapy
  • psychiatry
  • precision psychiatry
  • computational psychiatry
  • emotion regulation
  • process-based therapy
  • machine learning

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Published Papers (1 paper)

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Review

21 pages, 309 KB  
Review
Embodied Neuropsychodynamics of the Relational Self Across Space and Time: An Integrative Narrative Review
by Sharon Vaisvaser
Brain Sci. 2026, 16(6), 627; https://doi.org/10.3390/brainsci16060627 - 11 Jun 2026
Viewed by 205
Abstract
Extensive explorations in neuroscience, psychology, and psychotherapy increasingly recognized the embodied and relational foundations of selfhood, underscoring the need for an integrated framework spanning development, psychopathology, and therapeutic change. This narrative review synthesizes empirical and theoretical literature across neuroscience, embodiment research, predictive processing, [...] Read more.
Extensive explorations in neuroscience, psychology, and psychotherapy increasingly recognized the embodied and relational foundations of selfhood, underscoring the need for an integrated framework spanning development, psychopathology, and therapeutic change. This narrative review synthesizes empirical and theoretical literature across neuroscience, embodiment research, predictive processing, developmental science, phenomenology, and psychodynamic theory, proposing a multidimensional neuropsychodynamic framework of embodied selfhood and its clinical implications. A central contribution is the positioning of Peripersonal Space (PPS) as an embodied action-oriented interface that functions as a primary developmental scaffold for bodily self-consciousness, self-other relations, affect regulation and temporal continuity. PPS is proposed as a dynamic matrix linking embodied predictive self-processes with relational experience, thereby shaping subjective temporality and autobiographical processes. Within this framework, subjective time emerges through bodily rhythms, interpersonal synchronization, and predictive engagement with environmental affordances. These embodied temporal processes gradually extend toward autobiographical continuity and mentalizing capacities, supported by coordinated interactions among large-scale brain networks. Psychodynamic concepts including holding, containment, dimensionality, and symbolic transformation are revisited in dialogue with contemporary embodied and relational neuroscience. Clinically, disturbances of selfhood across psychopathological conditions are discussed in relation to altered PPS organization, disturbances in self-evidencing, and embodied temporal continuity. Psychotherapeutic change is conceptualized as involving gradual reorganization across embodied, affective, and reflective dimensions through co-regulation, interpersonal attunement, and temporally extended relational engagement. Overall, this perspective advances a process-oriented and interdisciplinary framework linking embodiment, temporality, autobiographical integration, and psychotherapy, while highlighting directions for future interdisciplinary research at the interface of neuroscience, embodiment and psychodynamics. Full article
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