Nano- and Micro-biosensing Technologies

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Nano- and Micro-Technologies in Biosensors".

Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 785

Special Issue Editor


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Guest Editor
College of Chemistry and Chemical Engineering, Qingdao University, Qingdao 266071, China
Interests: biomaterials; polymers; electrospinning; nanofibers; carbon nanotubes; sensors
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Special Issue Information

Dear Colleagues,

Nano- and micro-techniques, including nanomaterial synthesis, self-assembly, electrospinning, 3D printing, nanofabrication, microfabrication, and others, have been increasingly developed in recent years and contributed significantly to the design and construction of highly sensitive and selective sensors and biosensors. We propose a Special Issue on “Nano- and Micro-biosensing Technologies” to present advancements in this promising field. This collection primarily focuses on the technologies for synthesizing sensor architecture materials and fabricating high-performance biosensors.

Firstly, functional nanomaterials and micromaterials, incorporating metallic nanoparticles, quantum dots, nanotubes, and 2D materials, are needed to enhance the sensitivity and functionalities of biosensors. These synthesized materials fabricate various fluorescent, colorimetric, Raman spectral, surface plasmon resonance, electrochemical, and electric biosensors for the quick and sensitive detection of bioanalytes.

Secondly, to improve the selectivity of biosensors, specific bio-probes, such as antibodies, antigens, peptides, aptamers, and enzymes, are conjugated onto biosensor systems for the targeted determination of various biomolecules. Introducing bio-probes extends the applications of biosensors to trace the analysis of heavy metal ions, DNA, proteins, and disease biomarkers.

Additionally, advanced techniques, such as nanolithography, microfabrication, self-assembly, electrospinning, and 3D printing, are required to create nanoscale and microscale devices as biosensors, including field-effect transistors, microfluidic systems, wearable sensors, microelectrodes, and microarray sensors.

In addition, studies on other novel techniques for material synthesis, biosensor fabrication, and applications are welcome.

Prof. Dr. Gang Wei
Guest Editor

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Keywords

  • nanomaterials and micromaterials
  • nanozymes
  • hydrothermal synthesis
  • electrospinning
  • three-dimensional printing
  • self-assembly
  • nanofabrication
  • electrochemical biosensors
  • fluorescent biosensors
  • colorimetric biosensors
  • Raman spectroscopy-based biosensing techniques
  • wearable biosensors
  • FET biosensors

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Published Papers (1 paper)

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Review

38 pages, 7289 KiB  
Review
The Biomodification and Biomimetic Synthesis of 2D Nanomaterial-Based Nanohybrids for Biosensor Applications: A Review
by Ranran Wang, Xinyue Wang, Yan Wang and Gang Wei
Biosensors 2025, 15(5), 328; https://doi.org/10.3390/bios15050328 - 20 May 2025
Viewed by 351
Abstract
Two-dimensional nanomaterials (2DNMs) exhibit significant potential for the development of functional and specifically targeted biosensors, owing to their unique planar nanosheet structures and distinct physical and chemical properties. Biomodification and biomimetic synthesis offer green and mild approaches for the fabrication of multifunctional nanohybrids [...] Read more.
Two-dimensional nanomaterials (2DNMs) exhibit significant potential for the development of functional and specifically targeted biosensors, owing to their unique planar nanosheet structures and distinct physical and chemical properties. Biomodification and biomimetic synthesis offer green and mild approaches for the fabrication of multifunctional nanohybrids with enhanced catalytic, fluorescent, electronic, and optical properties, thereby expanding their utility in constructing high-performance biosensors. In this review, we present recent advances in the synthesis of 2DNM-based nanohybrids via both biomodification and biomimetic strategies for biosensor applications. We discuss covalent and non-covalent biomodification methods involving various biomolecules, including peptides, proteins, DNA/RNA, enzymes, biopolymers, and bioactive polysaccharides. The engineering of biomolecule–nanomaterial interfaces for the creation of biomodified 2DNM-based nanohybrids is also explored. Furthermore, we summarize the biomimetic synthesis of 2DNM-based bio–nanohybrids through pathways such as bio-templating, biomolecule-directed self-assembly, biomineralization, and biomimetic functional integration. The potential applications of these nanohybrids in diverse biosensing platforms—including colorimetric, surface plasmon resonance, electrochemical, fluorescence, photoelectrochemical, and integrated multimodal biosensors—are introduced and discussed. Finally, we analyze the opportunities and challenges associated with this rapidly developing field. We believe this comprehensive review will provide valuable insights into the biofunctionalization of 2DNMs and guide the rational design of advanced biosensors for diagnostic applications. Full article
(This article belongs to the Special Issue Nano- and Micro-biosensing Technologies)
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