Advances in Biomarker-Based Diagnostics: From Discovery to Clinical Application
A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 18
Special Issue Editor
2. Department of Biotechnology, School of Engineering and Applied Sciences, Bennett University, Greater Noida, UP, India
Interests: microfluidic bio-sensing; point-of-care diagnostics; microfluidic devices; lab-on-chip and molecular biosensing
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue, "Advances in Biomarker-Based Diagnostics: From Discovery to Clinical Application", showcases recent innovations in the discovery, validation, and clinical translation of molecular biomarkers. Biomarkers—spanning nucleic acids, proteins, metabolites, and extracellular vesicles—are increasingly central to precision diagnostics, offering insights into disease onset, progression, prognosis, and therapeutic responsiveness.
The integration of high-throughput omics technologies (genomics, proteomics, metabolomics), bioinformatics pipelines, and machine learning models has accelerated the identification of clinically actionable biomarkers. In parallel, advancements in biosensing platforms and microfluidic lab-on-a-chip systems are enabling the rapid, multiplexed, and minimally invasive detection of biomarkers from complex biological matrices, such as blood, saliva, and urine.
This Special Issue emphasizes the translational continuum from biomarker discovery and analytical validation to assay development, clinical performance evaluation, and regulatory considerations aligned with FDA, CLIA, and ISO standards. Contributions cover a spectrum of diagnostic modalities including liquid biopsies (e.g., ctDNA, exosomes), immunosensors, electrochemical biosensors, and microfluidic point-of-care devices.
Applications are illustrated across oncology, infectious diseases, neurodegenerative disorders, and cardiovascular diagnostics. Additionally, this Issue explores the challenges of standardization, reproducibility, and data integration.
By bridging molecular science with engineering and clinical practice, it aims to advance the development of next-generation diagnostics for personalized and predictive medicine. The scope of the Special Issue is broad and covers the following specified areas:
- Biomarker Discovery and Multi-Omics Approaches
– Identification and validation of novel biomarkers using genomics, proteomics, metabolomics, and integrative omics strategies. - Biosensors and Microfluidic Diagnostic Platforms
– Development and application of biosensing technologies, lab-on-a-chip systems, and microfluidic devices for rapid and sensitive biomarker detection. - Liquid Biopsy and Non-Invasive Diagnostics
– Advances in ctDNA, circulating tumor cells, exosomes, and other minimally invasive sampling methods for disease detection and monitoring. - AI and Computational Tools in Biomarker Interpretation
– Use of machine learning, deep learning, and bioinformatics to analyze biomarker data and support clinical decision-making. - Clinical Applications Across Disease Areas
– Implementation of biomarker diagnostics in oncology, infectious diseases, neurology, cardiovascular diseases, and autoimmune disorders. - Regulatory, Translational, and Ethical Considerations
– Clinical assay development, standardization, regulatory pathways (FDA, CE, CLIA), and ethical challenges in biomarker deployment.
Dr. Krishna Kant
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- biomarker
- diagnostics
- bio-sensing
- microfluidic sensing
- smart sensor
- multiplexed sensor
- lab-on-chip
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