Smart Materials and Sensing Strategies for Biomarker Detection
A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".
Deadline for manuscript submissions: 15 May 2026 | Viewed by 10
Special Issue Editor
2. Department of Biotechnology, School of Engineering and Applied Sciences, Bennett University, Greater Noida, UP, India
Interests: microfluidic bio-sensing; point-of-care diagnostics; microfluidic devices; lab-on-chip and molecular biosensing
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue, "Smart Materials and Sensing Strategies for Biomarker Detection," explores the interdisciplinary advances in the design and application of intelligent materials and sensor systems for the rapid, sensitive, and specific detection of biomarkers. With growing demands for early diagnosis, real-time monitoring, and personalized medicine, the integration of smart biomaterials with advanced biosensing platforms represents a transformative approach in biomedical diagnostics.
Smart materials—such as stimuli-responsive polymers, nanostructured materials, bioengineered hydrogels, and molecularly imprinted polymers—enable dynamic interactions with biological targets, enhancing the selectivity and sensitivity of biosensors. Combined with innovative sensing strategies (electrochemical, optical, piezoelectric, and microfluidic), these materials form the foundation of next-generation diagnostic devices capable of detecting a wide range of biomarkers including nucleic acids, proteins, metabolites, and extracellular vesicles.
This Issue invites contributions covering material design, sensor fabrication, surface functionalization, signal transduction mechanisms, and clinical validation. Special focus is given to point-of-care devices, wearable biosensors, implantable systems, and lab-on-a-chip platforms. Applications span oncology, infectious diseases, cardiovascular conditions, and neurological disorders.
By bringing together material science, sensor engineering, and clinical diagnostics, this Issue aims to advance the development of smart, integrated systems that will redefine the future of biomarker detection and healthcare delivery.
The scope includes, but is not limited to, the following areas:
- Design and Development of Smart Biomaterials
– Stimuli-responsive polymers, nanomaterials, hydrogels, molecularly imprinted polymers, and bioinspired materials for sensor applications. - Advanced Sensing Mechanisms and Platforms
– Electrochemical, optical, piezoelectric, and plasmonic sensors; microfluidic and lab-on-a-chip technologies. - Surface Functionalization and Biorecognition Interfaces
– Strategies for enhancing selectivity and sensitivity using aptamers, antibodies, peptides, and molecular imprinting. - Point-of-Care and Wearable Diagnostic Devices
– Integration of smart materials into portable, real-time biosensing systems for remote or personalized healthcare. - Detection of Diverse Biomarkers
– Sensing strategies for detecting nucleic acids, proteins, metabolites, exosomes, and disease-specific signatures across various clinical areas. - Translational Research and Clinical Validation
– Case studies, performance metrics, and regulatory perspectives for smart sensing platforms in real-world diagnostic applications.
Dr. Krishna Kant
Guest Editor
Manuscript Submission Information
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Keywords
- smart biomaterials
- biosensors
- biomarker detection
- point-of-care diagnostics
- microfluidic systems
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