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Open AccessArticle

Curcumin Attenuates Lead-Induced Cerebellar Toxicity in Rats via Chelating Activity and Inhibition of Oxidative Stress

1
Department of Human Anatomy, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor Darul Ehsan, Malaysia
2
Department of Human Anatomy, College of Medical Sciences, Federal University Lafia, P.M.B 146 Akunza, Lafia, Nasarawa State, Nigeria
3
Department of Veterinary Anatomy, Faculty of Veterinary Medicine, Usman Danfodiyo University, P.M.B 2346 Sokoto, Nigeria
4
Department of Human Anatomy, Faculty of Basic Medical Sciences, University of Maiduguri, Borno State, Nigeria
5
Department of Radiology, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor Darul Ehsan, Malaysia
6
Department of Preclinical Sciences Faculty of Veterinary Medicine, University Putra Malaysia, 43400 Serdang, Selangor Darul Ehsan, Malaysia
*
Authors to whom correspondence should be addressed.
Biomolecules 2019, 9(9), 453; https://doi.org/10.3390/biom9090453
Received: 21 June 2019 / Revised: 21 July 2019 / Accepted: 25 July 2019 / Published: 6 September 2019
(This article belongs to the Special Issue Oxidative Damage on Biomolecules and Antioxidants)
Lead (Pb) is a toxic, environmental heavy metal that induces serious clinical defects in all organs, with the nervous system being its primary target. Curcumin is the main active constituent of turmeric rhizome (Curcuma longa) with strong antioxidant and anti-inflammatory properties. This study is aimed at evaluating the therapeutic potentials of curcumin on Pb-induced neurotoxicity. Thirty-six male Sprague Dawley rats were randomly assigned into five groups with 12 rats in the control (normal saline) and 6 rats in each of groups, i.e., the lead-treated group (LTG) (50 mg/kg lead acetate for four weeks), recovery group (RC) (50 mg/kg lead acetate for four weeks), treatment group 1 (Cur100) (50 mg/kg lead acetate for four weeks, followed by 100 mg/kg curcumin for four weeks) and treatment group 2 (Cur200) (50 mg/kg lead acetate for four weeks, followed by 200 mg/kg curcumin for four weeks). All experimental groups received oral treatment via orogastric tube on alternate days. Motor function was assessed using a horizontal bar method. The cerebellar concentration of Pb was evaluated using ICP-MS technique. Pb-administered rats showed a significant decrease in motor scores and Superoxide Dismutase (SOD) activity with increased Malondialdehyde (MDA) levels. In addition, a marked increase in cerebellar Pb concentration and alterations in the histological architecture of the cerebellar cortex layers were recorded. However, treatment with curcumin improved the motor score, reduced Pb concentration in the cerebellum, and ameliorated the markers of oxidative stress, as well as restored the histological architecture of the cerebellum. The results of this study suggest that curcumin attenuates Pb-induced neurotoxicity via inhibition of oxidative stress and chelating activity. View Full-Text
Keywords: curcumin; lead toxicity; ICP-MS; horizontal bar; motor coordination; oxidative stress; cerebellum curcumin; lead toxicity; ICP-MS; horizontal bar; motor coordination; oxidative stress; cerebellum
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MDPI and ACS Style

Abubakar, K.; Muhammad Mailafiya, M.; Danmaigoro, A.; Musa Chiroma, S.; Abdul Rahim, E.B.; Abu Bakar @ Zakaria, M.Z. Curcumin Attenuates Lead-Induced Cerebellar Toxicity in Rats via Chelating Activity and Inhibition of Oxidative Stress. Biomolecules 2019, 9, 453. https://doi.org/10.3390/biom9090453

AMA Style

Abubakar K, Muhammad Mailafiya M, Danmaigoro A, Musa Chiroma S, Abdul Rahim EB, Abu Bakar @ Zakaria MZ. Curcumin Attenuates Lead-Induced Cerebellar Toxicity in Rats via Chelating Activity and Inhibition of Oxidative Stress. Biomolecules. 2019; 9(9):453. https://doi.org/10.3390/biom9090453

Chicago/Turabian Style

Abubakar, Kabeer; Muhammad Mailafiya, Maryam; Danmaigoro, Abubakar; Musa Chiroma, Samaila; Abdul Rahim, Ezamin B.; Abu Bakar @ Zakaria, Md Z. 2019. "Curcumin Attenuates Lead-Induced Cerebellar Toxicity in Rats via Chelating Activity and Inhibition of Oxidative Stress" Biomolecules 9, no. 9: 453. https://doi.org/10.3390/biom9090453

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