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Biomolecules
Special Issues
Biomarkers in Oral Diseases
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Biomarkers in Oral Diseases

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Biomarkers".

Deadline for manuscript submissions: closed (15 December 2021) | Viewed by 7376

Special Issue Editors

Dr. Agostino Guida

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Guest Editor
U.O.C. di Odontostomatologia, “AORN A. Cardarelli” Hospital, Via A. Cardarelli, 80131 Naples, Italy
Interests: oral potentially malignant disorders; oral squamous cell carcinoma; oral surgery
Special Issues, Collections and Topics in MDPI journals
Dr. Giuseppe Pannone

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Guest Editor
Department of Clinical and Experimental Medicine, University of Foggia, 70121 Foggia, Italy
Interests: head and neck oncology; head and neck squamous cell carcinoma; head and neck pathology
Special Issues, Collections and Topics in MDPI journals
Dr. Marco Annunziata

E-Mail Website
Guest Editor
Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy
Interests: periodontal diseases; implant dentistry; peri-implant diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As emerging from recent scientific literature, the identification of novel molecular biomarkers represents a most innovative and effective approach to both diagnosis and therapy. The stratification of patients through the investigation of variations in local/systemic levels of biomolecules may lead to the individualization of the whole pathway of care. Healthcare professionals—both clinicians and researchers—dedicated to oral health have taken up the challenge, in order to fill in the gaps with other medical specialties where individualized therapy is already a consolidated reality. For breast cancer and melanoma, genetic typing of the tumor/patient has led to the dramatic improvement of early diagnosis and the identification of therapeutic targets, effectively influencing prognosis and survival.

Diseases affecting the oral cavity are extremely heterogeneous, involving different medical specialists committed to both clinical and research activities. The aim of this Special Issue entitled “Biomarkers in Oral Diseases” is to encourage clinicians and basic researchers to share their findings regarding intracellular, histological, hematological, and cellular matrix biomarkers/biomolecules of teeth and mucosae, including oral, periodontal, and peri-implant tissues. From tooth decay to periodontal/peri-implant diseases, from oral potentially malignant disorders to oral squamous cell carcinoma with an eye on systemic diseases with oral manifestation, we encourage authors to submit both original articles and literature reviews regarding biomarkers in oral diseases. Articles/reviews highlighting an immediate diagnostic/therapeutic/clinical impact of the investigated biomarker(s) will be considered of particular interest.

We look forward to your contribution.

You may choose our Joint Special Issue in Pathogens.

Dr. Agostino Guida
Prof. Dr. Giuseppe Pannone
Prof. Dr. Marco Annunziata
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral potentially malignant disorders
  • oral squamous cell carcinoma
  • periodontal diseases
  • peri-implant diseases
  • head and neck pathology

Published Papers (2 papers)

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Research

17 pages, 4877 KiB  
Article
Expression of Beta-Catenin, Cadherins and P-Runx2 in Fibro-Osseous Lesions of the Jaw: Tissue Microarray Study
by Giuseppe Pannone, Riccardo Nocini, Angela Santoro, Francesca Spirito, Pier Francesco Nocini, Silvana Papagerakis, Renny T. Franceschi, Marina Di Domenico, Angelina Di Carlo, Nana Danelia and Lorenzo Lo Muzio
Biomolecules 2022, 12(4), 587; https://doi.org/10.3390/biom12040587 - 16 Apr 2022
Cited by 2 | Viewed by 2636
Abstract
Fibrous dysplasia (FD) and hyperparathyroidism-jaw tumor syndrome (HPT-JT) are well-characterized benign bone fibro-osseous lesions. The intracellular mechanism leading to excessive deposition of fibrous tissue and alteration of differentiation processes leading to osteomalacia have not yet been fully clarified. Tissue Microarray (TMA)-based immunohistochemical expression [...] Read more.
Fibrous dysplasia (FD) and hyperparathyroidism-jaw tumor syndrome (HPT-JT) are well-characterized benign bone fibro-osseous lesions. The intracellular mechanism leading to excessive deposition of fibrous tissue and alteration of differentiation processes leading to osteomalacia have not yet been fully clarified. Tissue Microarray (TMA)-based immunohistochemical expression of β-catenin, CK-AE1/AE3, Ki-67, cadherins and P-Runx2 were analyzed in archival samples from nine patients affected by FD and HPT-JT and in seven controls, with the aim of elucidating the contribution of these molecules (β-catenin, cadherins and P-Runx2) in the osteoblast differentiation pathway. β-catenin was strongly upregulated in FD, showing a hyper-cellulated pattern, while it was faintly expressed in bone tumors associated with HPT-JT. Furthermore, the loss of expression of OB-cadherin in osteoblast lineage in FD was accompanied by N-cadherin and P-cadherin upregulation (p < 0.05), while E-cadherin showed a minor role in these pathological processes. P-Runx2 showed over-expression in six out of eight cases of FD and stained moderately positive in the rimming lining osteoblasts in HPT-JT syndrome. β-catenin plays a central role in fibrous tissue proliferation and accompanies the lack of differentiation of osteoblast precursors in mature osteoblasts in FD. The study showed that the combined evaluation of the histological characteristics and the histochemical and immunohistochemical profile of key molecules involved in osteoblast differentiation are useful in the diagnosis, classification and therapeutic management of fibrous-osseous lesions. Full article
(This article belongs to the Special Issue Biomarkers in Oral Diseases)
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16 pages, 6698 KiB  
Article
Comprehensive Evaluation of PAXgene Fixation on Oral Cancer Tissues Using Routine Histology, Immunohistochemistry, and FTIR Microspectroscopy
by Pooja Lahiri, Suranjana Mukherjee, Biswajoy Ghosh, Debnath Das, Basudev Lahiri, Shailendra Kumar Varshney, Mousumi Pal, Ranjan Rashmi Paul and Jyotirmoy Chatterjee
Biomolecules 2021, 11(6), 889; https://doi.org/10.3390/biom11060889 - 15 Jun 2021
Cited by 1 | Viewed by 3928
Abstract
The choice of tissue fixation is critical for preserving the morphology and biochemical information of tissues. Fragile oral tissues with lower tensile strength are challenging to process for histological applications as they are prone to processing damage, such as tissue tear, wrinkling, and [...] Read more.
The choice of tissue fixation is critical for preserving the morphology and biochemical information of tissues. Fragile oral tissues with lower tensile strength are challenging to process for histological applications as they are prone to processing damage, such as tissue tear, wrinkling, and tissue fall-off from slides. This leads to loss of morphological information and unnecessary delay in experimentation. In this study, we have characterized the new PAXgene tissue fixation system on oral buccal mucosal tissue of cancerous and normal pathology for routine histological and immunohistochemical applications. We aimed to minimize the processing damage of tissues and improve the quality of histological experiments. We also examined the preservation of biomolecules by PAXgene fixation using FTIR microspectroscopy. Our results demonstrate that the PAXgene-fixed tissues showed significantly less tissue fall-off from slides. Hematoxylin and Eosin staining showed comparable morphology between formalin-fixed and PAXgene-fixed tissues. Good quality and slightly superior immunostaining for cancer-associated proteins p53 and CK5/6 were observed in PAXgene-fixed tissues without antigen retrieval than formalin-fixed tissues. Further, FTIR measurements revealed superior preservation of glycogen, fatty acids, and amide III protein secondary structures in PAXgene-fixed tissues. Overall, we present the first comprehensive evaluation of the PAXgene tissue fixation system in oral tissues. This study concludes that the PAXgene tissue fixation system can be applied to oral tissues to perform diagnostic molecular pathology experiments without compromising the quality of the morphology or biochemistry of biomolecules. Full article
(This article belongs to the Special Issue Biomarkers in Oral Diseases)
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