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Multidisciplinary Approach to Oral Cavity Cancer: An Hard Enemy
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Multidisciplinary Approach to Oral Cavity Cancer: An Hard Enemy

A special issue of Targets (ISSN 2813-3137).

Deadline for manuscript submissions: 20 September 2025 | Viewed by 1880

Special Issue Editors

Dr. Francesco Perri

E-Mail Website
Guest Editor
Istituto Nazionale Tumori di Napoli, IRCCS “G. Pascale”, Via Mariano Semmola, 80131 Napoli, Italy
Interests: head and neck oncology; immune-therapy; targeted therapy; pain therapy; electrochemotherapy; cancer diagnostics; treatment tumors; cancer biology; cancer biomarkers; tumor biology cancer; cell biology
Special Issues, Collections and Topics in MDPI journals
Dr. Agostino Guida

E-Mail Website
Guest Editor
U.O.C. di Odontostomatologia, “AORN A. Cardarelli” Hospital, Via A. Cardarelli, 80131 Naples, Italy
Interests: oral cavity disease; head and neck oncology; pathology; biology; biomarkers; precancerous lesions
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oral cancer represents the most frequent malignancy of the head and neck area. Head and neck tumors, in turn, represent 8% of all malignant tumors and the fifth most common cause of death from malignant tumors worldwide. Among head and neck cancers, oral cancer has the worst prognosis, despite therapeutic improvements over the last 10 years. Our only real defense against oral cancer, at present, is secondary prevention and, therefore, early diagnosis.

The upcoming Special Issue will contain original articles, reviews, and an editorial with the aim of underlining the importance of the multidisciplinary approach: namely, the initial classification of the patient being conducted by multiple specialists in this subject area (oncologists, surgeons, radiation oncologists, pathologists, etc.).

Dr. Francesco Perri
Dr. Agostino Guida
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Targets is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral cavity cancer
  • head and neck tumors
  • multidisciplinary approaches

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Published Papers (2 papers)

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Research

16 pages, 2599 KiB  
Article
Vitamin D Receptor and CYP450 Enzyme Dysregulation May Mediate Oral Cancer Responsiveness
by Dustin Hunsaker, James Landon Moore, Katherine M. Howard and Karl Kingsley
Targets 2025, 3(1), 6; https://doi.org/10.3390/targets3010006 - 8 Feb 2025
Viewed by 476
Abstract
Many health benefits are associated with Vitamin D (VitD), although deficiency is associated with poor health outcomes and the increased risk of cancer development. For example, many tissue-specific enzymes are involved in VitD metabolism, and mutations or deletions within Vitamin D receptor (VDR) [...] Read more.
Many health benefits are associated with Vitamin D (VitD), although deficiency is associated with poor health outcomes and the increased risk of cancer development. For example, many tissue-specific enzymes are involved in VitD metabolism, and mutations or deletions within Vitamin D receptor (VDR) genes are known to increase the cancer risk by altering their functions or bioavailability, although less is known about these phenomena in oral cancers. Using well-characterized, commercially available oral cell lines (OKF4, HGF-1, SCC4, SCC9, SCC15, SCC25, and CAL27), the mRNA expression of P450 cytochrome VitD metabolic enzymes and receptor genes by qPCR revealed differential results. One oral cancer line (SCC15) did not express either the Vitamin D receptor (VDR) or FOK1 polymorphism and was also least affected by VitD3 administration in growth assays. In contrast, most oral cancers were missing one or more hydrolase (CYP2R1 and CYP24A1) or hydrolate (CYP27A1 and CYP27B1) enzymes. SCC25 was missing both the hydrolate enzymes and was the most inhibited in the VitD3 growth assays, while SCC4 was missing both the hydroxylase enzymes and was the least inhibited by VitD2. These associations between mRNA expression (or lack thereof) and VitD3 and VitD2 responsiveness can be used to identify molecular targets, which may lead to effective screening tools for VitD-related, complementary and alternative therapies. Full article
(This article belongs to the Special Issue Multidisciplinary Approach to Oral Cavity Cancer: An Hard Enemy)
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11 pages, 3018 KiB  
Article
Identification of Biomarkers for Diagnosis and Prognosis of Head and Neck Cancer: Bioinformatics Approach
by Alexandra Fernandes and Rui Vitorino
Targets 2024, 2(4), 470-480; https://doi.org/10.3390/targets2040026 - 6 Dec 2024
Viewed by 962
Abstract
Head and neck cancer (HNC) is the seventh most commonly diagnosed malignancy worldwide, and its incidence is expected to increase in coming years. Current diagnostic methods for HNC are often limited by suboptimal accuracy and speed, which can negatively impact therapeutic decision-making and [...] Read more.
Head and neck cancer (HNC) is the seventh most commonly diagnosed malignancy worldwide, and its incidence is expected to increase in coming years. Current diagnostic methods for HNC are often limited by suboptimal accuracy and speed, which can negatively impact therapeutic decision-making and patient outcomes. To address the shortcomings of conventional diagnostics, biomarker detection has attracted increasing clinical interest as a promising alternative. However, a major challenge is the identification of biomarkers with sufficient accuracy and sensitivity for HNC. The integration of bioinformatics tools with omics data analysis has proven to be a robust approach for biomarker discovery. In this study, we outline a bioinformatics protocol aimed at identifying differentially expressed genes (DEGs) in HNC and evaluating the diagnostic and prognostic relevance of specific genes, including FN1, LGALS3, MMP9, TIMP1, MMP2, and TIMP2, in this pathology. In addition, we performed an enrichment analysis for the genes of interest. The prognostic significance of the selected genes was evaluated in relation to patient survival. This study contributes to the growing body of knowledge by identifying potential biomarkers with diagnostic and prognostic utility in this malignancy. Full article
(This article belongs to the Special Issue Multidisciplinary Approach to Oral Cavity Cancer: An Hard Enemy)
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