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Special Issue "Biomaterials and Biological Mediators for Periodontal and Bone Regeneration"

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: 31 March 2020.

Special Issue Editors

Guest Editor
Prof. Marco Annunziata

Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania “Luigi Vanvitelli”
Website | E-Mail
Interests: innovative materials and protocols in implant dentistry; periodontal and bone regenerative therapy; in vitro studies on primary periodontal cells and bone marrow mesenchymal stem cells; etiopathogenesis and therapy of periodontal and peri-implant disease
Guest Editor
Prof. Luigi Guida

Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania “Luigi Vanvitelli”
Website | E-Mail
Interests: etiopathogenesis, diagnosis and therapy of periodontal and peri-implant disease; periodontal and bone regenerative therapy; innovative operative protocols in implantology

Special Issue Information

Dear Colleagues,

As a matter of fact, the treatment of periodontitis represents a relevant public health challenge, with significant socio-economic implications. A large part of such treatment aims to preserve periodontal and bone tissue over time, but in case of tissue loss due to the disease progression the ultimate and most desirable therapeutic goal remains the rebuilding of lost tissues with tissues that are structurally and functionally the same: in few words periodontal and bone regeneration.

Dentistry probably represents one of the medical field in which the study and the utilization of innovative biomaterials and operative protocols for tissue reconstruction is much more present.

Autogenous, omologous, etherologous and synthetic bone grafts, resorbable and non-resorbable membranes, meshes, matrices, fixation pins or screws and other surgical devices, as well as inducing biological mediators, have been proposed and efficiently used to promote the reconstruction of both hard and soft tissues.

In this Special Issue on “Biomaterials and Biological Mediators for Periodontal and Bone Regeneration”, the aim will be to give an updated overview on the most stably recognized regenerative approaches and the most recent new developments for tissue regeneration.

Both pre-clinical and clinical studies are invited to be submitted, as well as narrative or systematic reviews, concerning the characterization of such biomaterials/biological mediators and their clinical applications for the regeneration of intraosseous periodontal defects and furcations, for soft tissue reconstruction (periodontal plastic surgery), for the preservation of post-extraction alveolar sockets and for the reconstruction of lateral and/or vertical bone defects before or contextually to dental implant placement for rehabilitative purposes.

Prof. Marco Annunziata
Prof. Luigi Guida
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Periodontal regeneration
  • Bone regeneration
  • Bone augmentation
  • Biomaterials
  • Biological mediators

Published Papers (3 papers)

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Review

Open AccessFeature PaperReview
Enamel Matrix Derivative and Autogenous Bone Graft for Periodontal Regeneration of Intrabony Defects in Humans: A Systematic Review and Meta-Analysis
Materials 2019, 12(16), 2634; https://doi.org/10.3390/ma12162634 (registering DOI)
Received: 22 July 2019 / Revised: 12 August 2019 / Accepted: 13 August 2019 / Published: 19 August 2019
PDF Full-text (1740 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
The combination of enamel matrix derivative (EMD) with an autogenous bone graft in periodontal regeneration has been proposed to improve clinical outcomes, especially in case of deep non-contained periodontal defects, with variable results. The aim of the present systematic review and meta-analysis was [...] Read more.
The combination of enamel matrix derivative (EMD) with an autogenous bone graft in periodontal regeneration has been proposed to improve clinical outcomes, especially in case of deep non-contained periodontal defects, with variable results. The aim of the present systematic review and meta-analysis was to assess the efficacy of EMD in combination with autogenous bone graft compared with the use of EMD alone for the regeneration of periodontal intrabony defects. A literature search in PubMed and in the Cochrane Central Register of Controlled Trials was carried out on February 2019 using an ad-hoc search string created by two independent and calibrated reviewers. All randomized controlled trials (RCTs) comparing a combination of EMD and autogenous bone graft with EMD alone for the treatment of periodontal intrabony defects were included. Studies involving other graft materials were excluded. The requested follow-up was at least 6 months. There was no restriction on age or number of patients. Standard difference in means between test and control groups as well as relative forest plots were calculated for clinical attachment level gain (CALgain), probing depth reduction (PDred), and gingival recession increase (RECinc). Three RCTs reporting on 79 patients and 98 intrabony defects were selected for the analysis. Statistical heterogeneity was detected as significantly high in the analysis of PDred and RECinc (I2 = 85.28%, p = 0.001; I2 = 73.95%, p = 0.022, respectively), but not in the analysis of CALgain (I2 = 59.30%, p = 0.086). Standard difference in means (SDM) for CALgain between test and control groups amounted to −0.34 mm (95% CI −0.77 to 0.09; p = 0.12). SDM for PDred amounted to −0.43 mm (95% CI −0.86 to 0.01; p = 0.06). SDM for RECinc amounted to 0.12 mm (95% CI −0.30 to 0.55. p = 0.57). Within their limits, the obtained results indicate that the combination of enamel matrix derivative and autogenous bone graft may result in non-significant additional clinical improvements in terms of CALgain, PDred, and RECinc compared with those obtained with EMD alone. Several factors, including the surgical protocol used (e.g. supracrestal soft tissue preservation techniques) could have masked the potential additional benefit of the combined approach. Further well-designed randomized controlled trials, with well-defined selection criteria and operative protocols, are needed to draw more definite conclusions. Full article
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Open AccessFeature PaperReview
New Perspectives in the Use of Biomaterials for Periodontal Regeneration
Materials 2019, 12(13), 2197; https://doi.org/10.3390/ma12132197
Received: 8 June 2019 / Revised: 1 July 2019 / Accepted: 2 July 2019 / Published: 8 July 2019
PDF Full-text (5791 KB) | HTML Full-text | XML Full-text
Abstract
Periodontitis is a disease with a high prevalence among adults. If not treated, it can lead to loss of teeth. Periodontal therapy aims at maintaining patient’s teeth through infection control and correction of non-maintainable anatomies including—when possible—regeneration of lost periodontal tissues. The biological [...] Read more.
Periodontitis is a disease with a high prevalence among adults. If not treated, it can lead to loss of teeth. Periodontal therapy aims at maintaining patient’s teeth through infection control and correction of non-maintainable anatomies including—when possible—regeneration of lost periodontal tissues. The biological regenerative potential of the periodontium is high, and several biomaterials can be utilized to improve the outcome of periodontal therapy. Use of different natural and synthetic materials in the periodontal field has been studied for many years. The main materials used today in periodontology analyzed in this review are: Resorbable and non-resorbable barrier membranes; autogenous, allogeneic, xenogeneic, and alloplastic bone substitutes; biological agents, such as amelogenins; platelet-derived growth factor; bone morphogenic proteins; rh fibroblast growth factor 2; teriparatide hormone; platelet concentrates; and 3D scaffolds. With the development of new surgical techniques some concepts on periodontal regeneration that were strictly applied in the past seem to be not so critical today. This can have an impact on the materials that are needed when attempting to regenerate lost periodontal structures. This review aims at presenting a rationale behind the use of biomaterials in modern periodontal regeneration Full article
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Open AccessReview
Fabrication of Scaffolds for Bone-Tissue Regeneration
Materials 2019, 12(4), 568; https://doi.org/10.3390/ma12040568
Received: 30 November 2018 / Revised: 8 February 2019 / Accepted: 11 February 2019 / Published: 14 February 2019
Cited by 7 | PDF Full-text (2727 KB) | HTML Full-text | XML Full-text
Abstract
The present article describes the state of the art in the rapidly developing field of bone tissue engineering, where many disciplines, such as material science, mechanical engineering, clinical medicine and genetics, are interconnected. The main objective is to restore and improve the function [...] Read more.
The present article describes the state of the art in the rapidly developing field of bone tissue engineering, where many disciplines, such as material science, mechanical engineering, clinical medicine and genetics, are interconnected. The main objective is to restore and improve the function of bone tissue by scaffolds, providing a suitable environment for tissue regeneration and repair. Strategies and materials used in oral regenerative therapies correspond to techniques generally used in bone tissue engineering. Researchers are focusing on developing and improving new materials to imitate the native biological neighborhood as authentically as possible. The most promising is a combination of cells and matrices (scaffolds) that can be fabricated from different kinds of materials. This review summarizes currently available materials and manufacturing technologies of scaffolds for bone-tissue regeneration. Full article
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

1. Enamel Matrix Derivatives as a soft tissue healing enhancer during periodontal plastic surgery procedures.

DISCEPOLI Nicola,  GENNAI Stefano,  FERRARI Marco.

2. Selection of collagen membranes for bone regeneration: a literature review.

SBRICOLI Luca, GUAZZO Riccardo, ANNUNZIATA Marco, NASTRI Livia, GOBBATO Luca, BRESSAN Eriberto.

3. The use of platelet derivatives in the regeneration of periodontal intrabony defects: qualitative assessment of systematic reviews.

ANNUNZIATA Marco, NASTRI Livia, CECORO Gennaro, MIGLIACCIO Rossella, RULLO Rosario, GUIDA Luigi

4. The use of enamel matrix derivatives and autogenous bone in the regeneration of periodontal intrabony defects: systematic review and meta-analysis.

ANNUNZIATA Marco, NASTRI Livia, CECORO Gennaro, Francesco PERILLO, Angelantonio PICCIRILLO, GUIDA Luigi

Materials EISSN 1996-1944 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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