Biomolecular Approaches and Drugs for Neurodegeneration

Dear Colleagues,

Neuropathies are very common and disabling neuropathies affecting the ever-growing aged population around the world, especially in Western countries. There is an urgent need to develop effective therapies for preventing or treating neuropathies. Protein/peptide aggregation is of fundamental importance in therapeutics because this type of event is related to pathologies of enormous social relevance, including neurodegeneration. Interestingly, G-quadruplex (G4) DNA and RNA structures are also related to several neuropathies, and ligands able to destabilize or modulate the aggregation of such nucleic acid secondary structures are therefore envisaged to work as neurodrugs. In this Special Issue, we wish to focus on the more recent experimental and theoretical approaches for neurodrug design and development, with particular attention paid to the mechanisms of drug interference with protein and peptide aggregation pathways; however, contributions on G4 nucleic acid–drug interaction, G4 targets in neurodegenerative diseases, and nucleopeptide chemistry are also welcome, as they could improve the overall knowledge on the aggregation-based biochemistry at the interface between neurodrug design and therapy. Other themes of interest are inherent the computational chemistry and machine learning applied to chemistry and biology in the context of neuropathology therapy. This Special Issue is open to the submission of both original articles and reviews that describe research and ideas on themes treated in this Special Issue for neurodegeneration-related molecular strategies.

Dr. Giovanni N. Roviello
Dr. Caterina Vicidomini
Guest Editors

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