Experimental and Theoretical Approaches to Protein-Targeting Drug Discovery

Dear Colleagues,

Protein-driven biological processes are of fundamental importance in biomedicine because they are related to pathologies of enormous social relevance, including cancer, neurodegeneration, and viral diseases, like the current COVID-19 pandemic. In this Special Issue, we wish to focus on the novel experimental and theoretical approaches for drug discovery, design, and development, with a particular attention being paid to the mechanisms of drug interference with protein-driven biological pathways. However, contributions on nucleic acid–protein interaction, peptide aggregation, nucleopeptide chemistry, and antimicrobial polyamino acids are also welcome, as they could improve overall knowledge on the amino acid-based biochemistry at the interface between drug design and therapy. Other themes of interest are inherent to the computational chemistry applied to protein and peptide science.

This Special Issue is open to the submission of both original articles and reviews that describe research and ideas on themes treated in this issue for protein-based molecular strategies.

Dr. Giovanni N. Roviello
Dr. Caterina Vicidomini
Guest Editors

Manuscript Submission Information

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