Bioactive Compounds and Therapeutics: Molecular Aspects, Metabolic Profiles, and Omics Studies 2nd Edition

Dear Colleagues,

Bioactive compounds can serve as drugs or inspire novel synthetic structures to be employed for treating numerous human illnesses, including cancer and COVID-19. Natural products, as well as synthetic compounds, represent a massive group of biologically active factors with potential roles in medical fields. For example, the antioxidant properties of phytomolecules may imply therapeutic agents. Nonetheless, significant attention is being devoted to the repositioning of ‘orphan drugs’ and repurposing existing drugs for novel medical scopes. In this context, dissecting the molecular connections with treatment and the metabolic response of a system are fundamental aspects to investigate. These strategies allow for the identification of pathways related to specific metabolites or proteins with a role in pathogenesis or the discovery of mechanistic insights important to preventing cellular damage and sequelae in patients. Nonetheless, the support offered by the latest state-of-the-art omics technologies can provide a global view of the effects generated by bioactive compounds in health and disease.

This Topic aims to collect experimental outcomes concerning the effects of molecules extracted from natural sources or chemically modified in synthetic/semisynthetic derivatives, with potential effects on human health. It will also welcome research papers, reviews, communications, etc., based on in vitro and in vivo molecular and biochemical assays, including biomolecular interactions, antioxidant analyses, proteomic and metabolomic profiling, and in silico investigations.

Dr. Michele Costanzo
Dr. Giovanni N. Roviello
Dr. Armando Cevenini
Topic Editors