Special Issue "Desiphering the Network of Cell Receptors and Matrix in Health and Disease"

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Natural and Bio-inspired Molecules".

Deadline for manuscript submissions: 15 May 2020.

Special Issue Editors

Prof. Marco Franchi
E-Mail Website
Guest Editor
Department for Life Quality Studies QUVI, Alma Mater Studiorum, University of Bologna, Italy
Interests: epithelial-to-mesenchymal transition; extracellular matrix; scanning electron microscope; collagen ultrastructure; cancer cell ultrastructure
Dr. Zoi Piperigkou
E-Mail Website
Guest Editor
1. Biochemistry, Biochemical Analysis & Matrix Pathobiology Research Group, Laboratory of Biochemistry, Chemistry Department, University of Patras, Greece
2 Foundation for Research and Technology-Hellas (FORTH)/ Institute of Chemical Engineering Sciences (ICE-HT), Patras, Greece
Interests: cancer; extracellular matrix; proteoglycans; estrogen receptors; matrix pathobiology; epigenetics

Special Issue Information

Dear Colleagues,

Extracellular matrices (ECMs) are specialized, dynamic scaffolds composed of a variety of functional macromolecules that interact with each other to mediate physiological functions of cells within tissues, such as cell proliferation, survival, migration, and differentiation, thus maintaining tissue functions and homeostasis. The basic ECM components involve proteoglycans (PGs), glycosaminoglycans, collagen, elastin, laminins, fibronectin, glycoproteins, and several matricellular proteins. Intriguingly, ECM molecules interact with resident cells through numerous cell surface receptors, including integrins, cell surface PGs, hyaluronan receptors, discoidin domain receptors (DDRs), and nonconventional receptors, such as growth factor receptors, toll-like receptors (TLRs), endothelial intracellular adhesion molecules (ICAMs) and transient receptor potential canonical (TRPCs) channels. Cell receptors transmit chemical and mechanical signals to ECMs that mediate cell responses, such as cell adhesion, differentiation and migration, cytoskeleton conformation, and cell signaling. Considering the critical roles of cell receptors in matrix assembly and cell functions, the benefit of understanding the complex mechanisms underlying their roles both in normal and in pathological conditions, such as fibrosis, osteoarthritis, genetic disorders, and cancer, arises. The scope of this Special Issue of Biomolecules, titled “Deciphering the Network of Cell Receptors and Matrix in Health and Disease”, is to welcome state-of-the-art reviews, original research articles, as well as short contributions that will address the significance of cell receptors in health and disease.

Prof. Marco Franchi
Dr. Zoi Piperigkou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Cell receptors
  • Extracellular matrix
  • Cell signaling
  • Biomarkers
  • Pharmacological targeting

Published Papers

This special issue is now open for submission.
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