Extracellular Matrix-mediated Cancer Cells
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Motility and Adhesion".
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 13908
Special Issue Editors
Interests: cancer invasion; extracellular matrix (ECM); epithelial-to-mesenchymal (EMT); 3D cultures; collagen
Special Issues, Collections and Topics in MDPI journals
Interests: extracellular matrix (ECM); epithelial-to-mesenchymal transition (EMT); cell plasticity; cell morphology; cell signaling
Special Issue Information
Dear Colleagues,
The extracellular matrix (ECM) is ubiquitously present in all connective tissues and represents the first microenvironment that cancer cells from solid tumors must invade to develop intravasation and then metastasis. Many researchers have exclusively focused their investigations on tumor features, but recent studies have demonstrated that tumor development and behavior have to be considered in view of the interactions and crosstalk between cancer cells and the surrounding stromal cells which could remodel a peritumoral ECM favoring cancer cell invasion. Exosomes and microvesicles, tunneling nanotubes, integrins, and signaling are all expressions of such an intense and strategic bidirectional interplay between tumor and ECM. Cancer growth and cancer cell invasion are strongly regulated both by changes of composition and structural array of peritumoral ECM, which can induce epithelial-to-mesenchymal transition (EMT). The aim of this Special Issue is to collect the expertise of international researchers to highlight the roles of intercellular as well as cell–tissue communications involved in cancer cell invasion and metastasis at distant sites.
Prof. Marco Franchi
Dr. Konstantina Kyriakopoulou
Guest Editors
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Keywords
- cancer invasion
- extracellular matrix (ECM)
- epithelial-to-mesenchymal (EMT)
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