Photothermal Therapy for Cancer Treatment

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 5298

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Institute for Bioengineering of Catalonia-IBEC, Barcelona, Spain
Interests: biomaterials; 3D models of disease; tissue engineering; cancer; bone
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Special Issue Information

Dear Colleagues,

Among the novel treatments that nanomedicine can offer, photothermal therapy (PTT) is one of the most promising strategies for cancer treatment. PTT involves designing photoactivatable nanocarriers, which can absorb nontoxic near-infrared light to produce heat inside the target cells, inducing cell death.

This Special Issue of Bioengineering on “Photothermal Therapy for Cancer Treatment” aims to collate original research papers and reviews that aim to provide a further understanding of PTT in the context of cancer research. The topics of interest for this Special Issue include, but are not limited to, the following:

  1. Novel and advanced nanomaterials for PTT;
  2. Studies of nanocarriers to transform near-infrared light into heat;
  3. Strategies to improve cancer PTT;
  4. Advanced strategies for nanomaterial functionalization for PTT;
  5. Approaches for improving specific cancer cell targeting;
  6. The development of tumor engineered models to validate the effect of PTT;
  7. Advanced techniques to track nanoparticles for PTT in in vivo and in tissue-engineered models;
  8. Advanced techniques for evaluating the effect of PTT in cancer cells.

Dr. Aranzazu Villasante
Guest Editor

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Keywords

  • photothermal therapy
  • cancer
  • nanomaterials
  • metallic nanostructures
  • functionalization of nanoparticles
  • nanomedicine

Published Papers (2 papers)

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Research

14 pages, 6957 KiB  
Article
Finite Element Models of Gold Nanoparticles and Their Suspensions for Photothermal Effect Calculation
by José Manuel Terrés-Haro, Javier Monreal-Trigo, Andy Hernández-Montoto, Francisco Javier Ibáñez-Civera, Rafael Masot-Peris and Ramón Martínez-Máñez
Bioengineering 2023, 10(2), 232; https://doi.org/10.3390/bioengineering10020232 - 9 Feb 2023
Cited by 2 | Viewed by 2626
Abstract
(1) Background: The ability of metal nanoparticles to carry other molecules and their electromagnetic interactions can be used for localized drug release or to heat malignant tissue, as in the case of photothermal treatments. Plasmonics can be used to calculate their absorption and [...] Read more.
(1) Background: The ability of metal nanoparticles to carry other molecules and their electromagnetic interactions can be used for localized drug release or to heat malignant tissue, as in the case of photothermal treatments. Plasmonics can be used to calculate their absorption and electric field enhancement, which can be further used to predict the outcome of photothermal experiments. In this study, we model the nanoparticle geometry in a Finite Element Model calculus environment to calculate the effects that occur as a response to placing it in an optical, electromagnetic field, and also a model of the experimental procedure to measure the temperature rise while irradiating a suspension of nanoparticles. (2) Methods: Finite Element Method numerical models using the COMSOL interface for geometry and mesh generation and iterative solving discretized Maxwell’s equations; (3) Results: Absorption and scattering cross-section spectrums were obtained for NanoRods and NanoStars, also varying their geometry as a parameter, along with electric field enhancement in their surroundings; temperature curves were calculated and measured as an outcome of the irradiation of different concentration suspensions; (4) Conclusions: The results obtained are comparable with the bibliography and experimental measurements. Full article
(This article belongs to the Special Issue Photothermal Therapy for Cancer Treatment)
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7 pages, 1626 KiB  
Communication
Highly Purified Conjugates of Natural Chlorin with Cobalt Bis(dicarbollide) Nanoclusters for PDT and BNCT Therapy of Cancer
by Maria K. Fedotova, Maksim N. Usachev, Ekaterina V. Bogdanova, Ekaterina Diachkova, Yuriy Vasil’ev, Vladimir I. Bregadze, Andrey F. Mironov and Mikhail A. Grin
Bioengineering 2022, 9(1), 5; https://doi.org/10.3390/bioengineering9010005 - 25 Dec 2021
Cited by 3 | Viewed by 2516
Abstract
To combine the neutron-capturing and photodynamic properties of boron nanoclusters and derivatives of natural chlorins, respectively, in one molecule, conjugate of chlorin e6 methyl ester with cyclen and dioxane and nitrile derivatives of cobalt bis(dicarbollide) were synthesized. The conditions for the purification of [...] Read more.
To combine the neutron-capturing and photodynamic properties of boron nanoclusters and derivatives of natural chlorins, respectively, in one molecule, conjugate of chlorin e6 methyl ester with cyclen and dioxane and nitrile derivatives of cobalt bis(dicarbollide) were synthesized. The conditions for the purification of compounds by HPLC were selected since the work with natural compounds is complicated by the production of closely related impurities. Full article
(This article belongs to the Special Issue Photothermal Therapy for Cancer Treatment)
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