Ophthalmic Engineering (3rd Edition)

A special issue of Bioengineering (ISSN 2306-5354). This special issue belongs to the section "Regenerative Engineering".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1119

Special Issue Editor


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Guest Editor
School of Biological Science and Medical Engineering, Beihang University, Beijing, China
Interests: biomechanics; ophthalmology; image processing; artificial intelligence; eye movement
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is the third edition of the previous releases, "Ophthalmic Engineering” (https://www.mdpi.com/journal/bioengineering/special_issues/Ophthalmic_Engineering) and “Ophthalmic Engineering (2nd Edition)" (https://www.mdpi.com/journal/bioengineering/special_issues/0078L520K4)

The majority of people rely on their eyes to perceive and make sense of the world. However, the eye and the visual system are vulnerable to diseases and disorders at every stage of life. At present, at least 2.2 billion people around the world have a vision impairment, according to the World Report on Vision by the WHO.

Recent advances in bioengineering are conveying exciting changes to the field of ophthalmology and visual science. Engineering methods such as biomechanics, novel imaging modalities, tissue engineering, virtual reality, and artificial intelligence have exhibited great success with regard to diagnosing, treating, and understanding the mechanisms of various eye diseases.

In this Special Issue, we will focus on the vast range of potential bioengineering methods to be applied and their applications in ophthalmology and visual science. Both original research contributions and review papers are welcome. Topics may include, but are not limited to, the following:

  • Ocular biomechanics;
  • Ophthalmic imaging;
  • Artificial intelligence in ophthalmology;
  • Virtual reality;
  • Biomolecular, cellular, and tissue engineering in ophthalmology;
  • Novel diagnostic and treatment methods in ophthalmology;
  • Material characterization of ocular tissue.

Prof. Dr. Xiaofei Wang
Guest Editor

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Keywords

  • ophthalmology
  • biomechanics
  • eye
  • medical imaging
  • optical coherence tomography
  • artificial intelligence
  • deep learning
  • virtual reality
  • medical device
  • finite element method
  • inverse analysis

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Published Papers (1 paper)

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Research

23 pages, 15758 KiB  
Article
Study on the Polarization of Astrocytes in the Optic Nerve Head of Rats Under High Intraocular Pressure: In Vitro
by Bochao Ma, Jifeng Ren and Xiuqing Qian
Bioengineering 2025, 12(2), 104; https://doi.org/10.3390/bioengineering12020104 - 23 Jan 2025
Cited by 1 | Viewed by 898
Abstract
Astrocytes, the most common glial cells in the optic nerve head (ONH), provide support and nutrition to retinal ganglion cells. This study aims to investigate the polarization types of astrocytes in the ONH of rats under high intraocular pressure (IOP) and explore signaling [...] Read more.
Astrocytes, the most common glial cells in the optic nerve head (ONH), provide support and nutrition to retinal ganglion cells. This study aims to investigate the polarization types of astrocytes in the ONH of rats under high intraocular pressure (IOP) and explore signaling pathways potentially associated with different types of polarized astrocytes. The rat models with chronic high IOP were established. High IOP lasted for 2, 4, 6, and 8 weeks. Astrocytes were extracted from the ONH of rats using the tissue block cultivation method. Western blot was used to detect the expression of proteins associated with astrocyte polarization. Proteomics was employed to identify differential proteins associated with astrocyte polarization. Astrocytes polarized into A2 astrocytes after 2, 4, 6, and 8 weeks of high IOP, while polarization into A1 astrocytes began only after 8 weeks of high IOP. The differential proteins associated with A1 astrocyte polarization are primarily enriched in pathways of neurodegeneration with respect to multiple diseases, while the differential proteins associated with A2 astrocyte polarization are primarily enriched in pathways of spliceosome in amyotrophic lateral sclerosis. Our findings could provide a better understanding of the role of ONH astrocytes in the pathogenesis of glaucoma and offer new perspectives for glaucoma treatment. Full article
(This article belongs to the Special Issue Ophthalmic Engineering (3rd Edition))
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