Stem Cell Dysfunction in Diabetes: Causes, Consequences, and Therapeutics for Regenerative Medicine

Dear Colleagues,

Diabetes is associated with micro- and macrovascular complications that are the most prevalent causes of mortality and morbidity in diabetic patients. Over the years, numerous studies have demonstrated that diabetic complications are the result of molecular alteration, mainly induced by hyperglycemia, in a wide range of cell types, including stem cells. Stem cells and progenitor cells, through their ability to self-renew and commit to specialized effector cells, play an integral role in the maintenance of tissue homeostasis and repair. Their functional aberrations, which seem to persist even after return to normoglycemia (hyperglycemic memory), have direct implications on tissue function and in the pathogenesis of diabetic complication. The study of the molecular and epigenetic mechanisms involved in the alteration of stem cell biology has become attractive for understanding the pathophysiology of diabetic complications and for discovering novel therapies.

For this Special Issue of Applied Sciences, the following topics are welcomed: molecular and epigenetic mechanisms involved in diabetic stem cell dysfunction; consequences of diabetic stem cell alterations in regenerative medicine; and new therapeutic and molecular strategies in treating stem cells dysfunction. Further innovative proposals will be evaluated.

Dr. Maria Cristina Vinci
Guest Editor

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