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Next-Generation Drug Delivery Technology and Drug Design

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Chemical and Molecular Sciences".

Deadline for manuscript submissions: 20 November 2025 | Viewed by 1210

Special Issue Editors


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Guest Editor
Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, 15784 Athens, Greece
Interests: drug carriers; drug delivery; biopolymers; nanotechnology; nanomaterials
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Section of Pharmaceutical Technology, Department of Pharmacy, National and Kapodistrian University of Athens, 15784 Athens, Greece
Interests: drug delivery; controlled release; modified release; statistical analysis; melatonin; tablet; formulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Drug discovery and development is multifaceted, allowing researchers to expand their quiver of therapeutic modalities to treat and manage serious ailments. Concurrently, the systems and approaches that can be used to deliver medicine are advancing at an unprecedented rate; thus, becoming familiar with the advances in drug delivery has important implications for anyone involved in health care and related sectors.

This Special Issue offers contributors the opportunity to publish their research on various drug modalities, including small compounds, protein and nucleic acid systems, cell therapies, etc., enabling both the cognizant and non-cognizant reader to be navigated to the foundational and state-of-the-art methodologies in developing novel therapeutics, including personalized drugs.

Dr. Marilena Vlachou
Dr. Angeliki Siamidi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug discovery
  • small and non-small molecules
  • drug development
  • tailor-made drugs
  • future perspectives

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Published Papers (1 paper)

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Research

17 pages, 2607 KiB  
Article
Release Behavior of the Pineal Hormone Melatonin from Modified Matrix Tablets Based on Poly(L-Lactic Acid) and Its Derivatives
by Marilena Vlachou, Georgios-Marios Bolbasis, Anna-Evaggelia Trikali, Chrystalla Protopapa, Angeliki Siamidi, Aikaterini Sakellaropoulou, Evi Christodoulou and Nikolaos D. Bikiaris
Appl. Sci. 2025, 15(4), 2054; https://doi.org/10.3390/app15042054 - 16 Feb 2025
Cited by 1 | Viewed by 898
Abstract
Biodegradable polyesters have been researched intensively over the last two decades because of their biodegradability and superb physical properties. However, the use of linear biodegradable polyesters, for the preparation of drug delivery systems (DDS), is hampered by several limitations. In view of this, [...] Read more.
Biodegradable polyesters have been researched intensively over the last two decades because of their biodegradability and superb physical properties. However, the use of linear biodegradable polyesters, for the preparation of drug delivery systems (DDS), is hampered by several limitations. In view of this, scientific attention has been shifted to the employment of branched-chain (co-)polymers. In this context, we present herein the development of new melatonin (MLT) tablet formulations, using novel branched polylactide (PLA)-based copolymers of different architectures. Specifically, three PLA-polyol branched polyesters, namely, a three-arm copolymer based on glycerol (PLA-glycerol), a four-arm copolymer based on pentaerythritol (PLA-pentaerythritol), and a six-arm copolymer based on sorbitol (PLA-sorbitol), were utilized. The presence of these polyesters in the formulations was found to be crucial, as the sought MLT release, regarding its use in confronting sleep onset and/or sleep maintenance dysfunctions, was achieved. The copresence of the other excipients in the matrix tablets (lactose monohydrate, hydroxypropylmethylcellulose, microcrystalline cellulose, and sodium alginate) led to a concentration-dependent synergistic effect on the MLT release. To the best of our knowledge, this is the first investigation with these specific polymeric materials, concerning MLT modified release from matrix tablets. Full article
(This article belongs to the Special Issue Next-Generation Drug Delivery Technology and Drug Design)
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