Network Medicine Approaches in Ageing Research

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Biomedical Engineering".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 3019

Special Issue Editors


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Guest Editor
Department of Medical and Surgical Sciences, University Magna Græcia of Catanzaro, 88100 Catanzaro, Italy
Interests: molecular biology; PCR; DNA; sequencing; genetics; data analysis; insulin resistance; evolutionary biology; genotyping; biochemistry; genomics

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Guest Editor
Department of Molecular Medicine, Sapienza University of Rome, Viale Regina Elena 291, 00161 Rome, Italy
Interests: bio-inspired molecular dynamics simulation techniques

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Guest Editor
Soverato Hospital ASP Catanzaro, 88068 Soverato, Italy
Interests: diabetes; aging; long term care; molecular sciences
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Special Issue Information

Dear Colleagues,

Network medicine helps to provide insight into many chronic diseases by offering useful information about mechanistic information from omics data sets. Many diseases show different progression and different lethality in different ages and sexes. There are many different molecular processes that may be related to such aging processes that need to be elucidated. This elucidation is the first step in a personalized medicine approach. There are currently some different databases storing omics data related to aging (such as epigenetic data, methylation, as well as transcriptomic data annotated with patients’ age). Therefore, there is a need to introduce novel algorithms and models able to integrate and shed light on such processes.

This Special Issue aims to highlight novel research and applications in this area, coupled with representation learning and its implementations in biology, medicine, and pharmacology.

The Special Issue is focused on, but not limited to, the following broad areas:

  • Network-based analysis in aging;
  • Graph convolution neural networks;
  • Network embedding in aging;
  • Data integration;
  • Drug discovery through network medicine in aging.

Prof. Dr. Pietro Hiram Guzzi
Dr. Gaia C. Mannino
Dr. Francesco Petrizzelli
Dr. Elisabetta Pedace
Guest Editors

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Keywords

  • ageing network analysis
  • artificialel intelligence

Published Papers (2 papers)

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Research

17 pages, 623 KiB  
Article
Will Artificial Intelligence Provide Answers to Current Gaps and Needs in Chronic Heart Failure?
by Fabiola Boccuto, Salvatore De Rosa, Daniele Torella, Pierangelo Veltri and Pietro Hiram Guzzi
Appl. Sci. 2023, 13(13), 7663; https://doi.org/10.3390/app13137663 - 28 Jun 2023
Cited by 1 | Viewed by 1329
Abstract
Chronic heart failure (CHF) is a prevalent and multifactorial condition associated with a significant burden of morbidity and mortality. Despite progress in its clinical management, the projected increase in CHF prevalence due to population ageing, increased cardiovascular risk burdens, and advancing diagnostic and [...] Read more.
Chronic heart failure (CHF) is a prevalent and multifactorial condition associated with a significant burden of morbidity and mortality. Despite progress in its clinical management, the projected increase in CHF prevalence due to population ageing, increased cardiovascular risk burdens, and advancing diagnostic and therapeutic options have led to a growing burden on healthcare systems and public budgets worldwide. In this context, artificial intelligence (AI) holds promise in assisting clinical decision-making, especially in analysing raw image data and electrocardiogram recordings. This article provides an overview of the current gaps and needs in CHF research and clinical management and the current and under-development AI-powered tools that may address these gaps and needs. Full article
(This article belongs to the Special Issue Network Medicine Approaches in Ageing Research)
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15 pages, 4328 KiB  
Article
Investigating Mitochondrial Gene Expression Patterns in Drosophila melanogaster Using Network Analysis to Understand Aging Mechanisms
by Manuel Mangoni, Francesco Petrizzelli, Niccolò Liorni, Salvatore Daniele Bianco, Tommaso Biagini, Alessandro Napoli, Marta Adinolfi, Pietro Hiram Guzzi, Antonio Novelli, Viviana Caputo and Tommaso Mazza
Appl. Sci. 2023, 13(12), 7342; https://doi.org/10.3390/app13127342 - 20 Jun 2023
Cited by 1 | Viewed by 1162
Abstract
The process of aging is a complex phenomenon that involves a progressive decline in physiological functions required for survival and fertility. To better understand the mechanisms underlying this process, the scientific community has utilized several tools. Among them, mitochondrial DNA has emerged as [...] Read more.
The process of aging is a complex phenomenon that involves a progressive decline in physiological functions required for survival and fertility. To better understand the mechanisms underlying this process, the scientific community has utilized several tools. Among them, mitochondrial DNA has emerged as a crucial factor in biological aging, given that mitochondrial dysfunction is thought to significantly contribute to this phenomenon. Additionally, Drosophila melanogaster has proven to be a valuable model organism for studying aging due to its low cost, capacity to generate large populations, and ease of genetic manipulation and tissue dissection. Moreover, graph theory has been employed to understand the dynamic changes in gene expression patterns associated with aging and to investigate the interactions between aging and aging-related diseases. In this study, we have integrated these approaches to examine the patterns of gene co-expression in Drosophila melanogaster at various stages of development. By applying graph-theory techniques, we have identified modules of co-expressing genes, highlighting those that contain a significantly high number of mitochondrial genes. We found important mitochondrial genes involved in aging and age-related diseases in Drosophila melanogaster, including UQCR-C1, ND-B17.2, ND-20, and Pdhb. Our findings shed light on the role of mitochondrial genes in the aging process and demonstrate the utility of Drosophila melanogaster as a model organism and graph theory in aging research. Full article
(This article belongs to the Special Issue Network Medicine Approaches in Ageing Research)
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