Advances in Structural Biology Methods
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".
Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 442
Special Issue Editor
2. School of Biological, Earth & Environmental Sciences, University of New South Wales, Sydney, NSW 2052, Australia;
3. School of Chemistry, Griffith University, Brisbane, QLD 4101, Australia;
4. Department of Physiology & Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Interests: mass spectrometry; disease pathogenesis associated with protein structure and oxidative damage; elemental profiling to combat illegal wildlife trafficking; eNose sensors with applications in environmental, medicine, and wildlife conservation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Advances in structural biology methods rely on the development of analytical procedures. This Special Issue invites articles on:
- Complementary techniques that have revolutionalised the study of protein structure and dynamics, such as “hydrogen-deuterium exchange” combined with NMR spectroscopy or mass spectrometry, which have made possible to visualise kinetics of protein folding at amino acid resolution; tryptophan fluorescence spectroscopy that has enabled capturing local structural changes and dynamics of proteins on fast time scales (e.g. picoseconds); X-ray crystallography as an invaluable tool that continues to contribute greatly to protein structure determination;
- Pioneering methods of Protein Footprinting coupled with mass spectrometry, also referred to as "Radical Probe Mass Spectrometry (RPMS)", or “Synchrotron X-Ray Radiolysis”, which enable the study of three-dimensional protein structures, folding and macromolecular interactions dynamics on fast timescales (down to sub-milliseconds); including reviews of this fast growing technology, covering advances of hydroxyl radical production, updates in capabilities of Synchrotron Facilities, and a range of biological and pharmaceutical applications of protein footprinting;
- Historical perspectives and emerging techniques applied to the study of protein structure and dynamics.
This Special Issue initiative invites articles with an overview of this fast-growing technology, covering advances of hydroxyl radical production, updates in capabilities of synchrotron facilities, and a range of biological and pharmaceutical applications of protein footprinting.
Dr. Simin D. Maleknia
Guest Editor
Manuscript Submission Information
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Keywords
- Radical probe mass spectrometry (RP-MS)
- Synchrotron X-ray radiolysis
- Hydroxyl radical protein footprinting (HRPF)
- Xray footprinting with mass spectrometry (XF-MS)
- Fast photochemical oxidation of proteins (FPOP)
- Protein structure
- Protein–ligand interactions
- Protein aggregates
- Amyloidosis
- Oxidative damage
- Protein folding and misfolding
- Protein DNA interactions
- Protein RNA interactions
- Structural proteomics
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