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Applied Sciences
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Multifunctional Materials for Biomedical Application
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Multifunctional Materials for Biomedical Application

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Materials Science and Engineering".

Deadline for manuscript submissions: closed (20 December 2021) | Viewed by 5777

Special Issue Editors

Prof. Dr. Agnese Magnani

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Guest Editor
1. Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via Aldo Moro 3, 53100 Siena, Italy
2. National Interuniversity Consortium (INSTM), Florence, Italy
3. Center for Colloids and Surface Science (CSGI), Florence, Italy
Interests: biomaterials; hydrogels; nanocarriers; biosensors; surface characterization; regenerative medicine; hyaluronic acid
Special Issues, Collections and Topics in MDPI journals
Dr. Gemma Leone

E-Mail Website1 Website2
Guest Editor
Department of Biotechnology, Chemistry and Pharmacy, University of Siena, 53100 Siena SI, Italy
Interests: biomaterials; hydrogels; nanocarriers; biosensors; thermal and rheological characterization; regenerative medicine

Special Issue Information

Dear Colleagues,

The ageing of modern societies, followed by the growing prevalence of diseases of civilization, leaves biomedicine currently facing the urgent need to develop new treatments and therapeutic strategies to promote the healing of a damaged tissue or to enhance the functional recovery of an organ.

Development in the field of biomedical materials is outstanding, driven not only by the target application in terms of regenerative medicine, but also by the advances in materials and nanomaterials synthesis, fabrication, and characterization techniques.

Multifunctional materials draw attention in various biomedical applications, thanks to their customizable structures and functions to guide and control their interaction with specific target molecules, cells, and tissues.

In this sense, they represent versatile platforms for a broad range of applications with potential use in numerous biomedical areas, including regenerative medicine, tissue engineering, drug delivery, diagnostics and sensing, in vitro and in vivo imaging and therapeutic techniques.

This Special Issue on “Multifunctional Materials for Biomedical Applications” focuses on research related to the design, synthesis, and fabrication of multifunctional materials as well as to their physicochemical and biological characterization.

Full articles, short communications, and review articles are welcome.

Prof. Dr. Agnese Magnani
Dr. Gemma Leone
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • multifunctional materials
  • biomaterials
  • hydrogels
  • polymeric materials
  • hybrid materials
  • biodegradable materials
  • nanomaterials
  • biocompatibility
  • regenerative medicine
  • tissue engineering
  • drug delivery systems
  • sensors and biosensors

Published Papers (2 papers)

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Research

12 pages, 2050 KiB  
Article
Physicochemical Characterization of Hyaluronic Acid and Chitosan Liposome Coatings
by Claudia Bonechi, Gabriella Tamasi, Alessandro Donati, Gemma Leone, Marco Consumi, Lorenzo Cangeloni, Vanessa Volpi, Agnese Magnani, Andrea Cappelli and Claudio Rossi
Appl. Sci. 2021, 11(24), 12071; https://doi.org/10.3390/app112412071 - 17 Dec 2021
Cited by 5 | Viewed by 3143
Abstract
Hyaluronic acid (HA) and chitosan (CH) are biopolymers that are widely used in many biomedical applications and for cosmetic purposes. Their chemical properties are fundamental to them working as drug delivery systems and improving their synergistic effects. In this work, two different protocols [...] Read more.
Hyaluronic acid (HA) and chitosan (CH) are biopolymers that are widely used in many biomedical applications and for cosmetic purposes. Their chemical properties are fundamental to them working as drug delivery systems and improving their synergistic effects. In this work, two different protocols were used to obtain zwitterionic liposomes coated with either hyaluronic acid or chitosan. Specifically, the methodologies used to perform vesicle preparation were chosen by taking into account the specific chemical properties of these two polysaccharides. In the case of chitosan, liposomes were first synthesized and then coated, whereas the coating of hyaluronic acid was achieved through lipidic film hydration in an HA aqueous solution. The size and the zeta-potential of the polysaccharide-coated liposomes were determined by dynamic light scattering (DLS). This approach allowed coated liposomes to be obtained with hydrodynamic diameters of 264.4 ± 12.5 and 450.3 ± 16.7 nm for HA- and CH-coated liposomes, respectively. The chemical characterization of the coated liposomal systems was obtained by surface infrared (ATR-FTIR) and nuclear magnetic resonance (NMR) spectroscopies. In particular, the presence of polysaccharides was confirmed by the bands assigned to amides and saccharides being in the 1500–1700 cm−1 and 800–1100 cm−1 regions, respectively. This approach allowed confirmation of the efficiency of the coating processes, evidencing the presence of HA or CH at the liposomal surface. These data were also supported by time-of-flight secondary ion mass spectrometry (ToF-SIMS), which provided specific assessments of surface (3–5 nm deep) composition and structure of the polysaccharide-coated liposomes. In this work, the synthesis and the physical chemistry characterization of coated liposomes with HA or CH represent an important step in improving the pharmacological properties of drug delivery systems. Full article
(This article belongs to the Special Issue Multifunctional Materials for Biomedical Application)
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10 pages, 1535 KiB  
Article
Therapeutic Hydrogel Lenses and the Antibacterial and Antibiotic Drugs Release
by Alessandra Pulliero, Aldo Profumo, Camillo Rosano, Alberto Izzotti and Sergio Claudio Saccà
Appl. Sci. 2021, 11(4), 1931; https://doi.org/10.3390/app11041931 - 22 Feb 2021
Cited by 4 | Viewed by 1971
Abstract
The aim of this research was to evaluate the effects of different lens types on the availability and efficacy of anti-inflammatory and antibiotic drugs. Three lens types were examined: (1) nonionic hydrogel lenses; (2) ionic hydrogel lenses; and (3) silicone hydrogel lenses. The [...] Read more.
The aim of this research was to evaluate the effects of different lens types on the availability and efficacy of anti-inflammatory and antibiotic drugs. Three lens types were examined: (1) nonionic hydrogel lenses; (2) ionic hydrogel lenses; and (3) silicone hydrogel lenses. The lenses were incubated with (a) dexamethasone; (b) betamethasone; (c) bromophenacyl bromide; and (d) chloramphenicol. Drug availability was quantified by gradient HPLC, and chloramphenicol antibacterial activity was quantified by testing the inhibition of Salmonella typhimurium growth on agar. The lens allowing the most abundant passage of betamethasone was the ionic hydrogel lens, followed by the silicone hydrogel lens and nonionic hydrogel lens. The lens allowing the most abundant passage of dexamethasone was the ionic hydrogel lens, but only at 0.5 h and 1 h. Regarding chloramphenicol, the ionic hydrogel lens and silicone hydrogel lens allowed more abundant passage than the nonionic hydrogel lens. These results highlight the relevance of adapting lenses to anti-inflammatory therapy, thus allowing a personalized medical approach. Full article
(This article belongs to the Special Issue Multifunctional Materials for Biomedical Application)
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