Oxidative Stress in Human Disease and Ageing: Insights and Innovations

Dear Colleagues,

It is well known that the ageing process, an inherent characteristic of the human life cycle, is associated with a progressive decrease in cellular machinery, both biochemically and physiologically. In this scenario, the increase in ROS/RNS impacts cellular dynamics, causing oxidative stress, which, in turn, can lead to adaptation or cell injury. In the first one, the cells usually tolerate mild oxidative stress, leading to the upregulation of the antioxidant defence system. However, in the second one, there is a transient or permanent alteration of cellular homeostasis. In addition to ageing, a growing number of chronic diseases are also associated with oxidative stress, including neurodegenerative and psychiatric diseases, atherosclerosis, diabetes, hypertension, auto-immune diseases, and cancer, among others. Still, there are many gaps in the existing literature regarding the response to oxidative stress throughout life that culminates in these outcomes. Therefore, we would like to invite global research groups to contribute to this Special Issue. Manuscripts addressing the mechanisms of free-radical reactions in human disease and ageing and the evidence that antioxidant defence systems could help with ageing are welcome.

Warm regards,

Prof. Dr. Catia Branco
Guest Editor

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