Molecular Mechanisms, Diagnosis and Therapeutics of Neurodegenerative Diseases
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Biomedical Engineering".
Deadline for manuscript submissions: 30 May 2025 | Viewed by 1073
Special Issue Editor
Interests: neurodegenerative disease; aggregation biology; proteostasis; neuromorphology; natural compounds; protein quality control system
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurodegenerative diseases like Alzheimer’s, Parkinson’s, Amyotrophic lateral sclerosis, and Huntington's disease are the most conventional neuronal issues that are causing a dreadful burden in the global healthcare system. Neurodegenerative diseases are complex ailments of the neurons characterized by neuronal decay, reduced cognitive function, and dementia. The primary etiology of neurodegeneration includes ageing, stress, and genetics. However, the molecular basis of these diseases is more complex, including protein misfolding and the formation of toxic aggregates. Understanding the feature mechanisms of neurodegenerative diseases and finding their cure is one of the most paramount research fields in today’s science world because the number of patients suffering from these conditions is escalating. Early detection of these conditions can be a key game-changer in neurodegeneration research as disease conditions can be improved by early treatment. Appropriate management and therapeutic application are necessary to maintain the patients’ well-being and slow disease progression. Exploring natural compounds, especially neurotropic elements, de novo neurotropic small molecules, gene-based therapies, and combination therapies of different existing medicines can allow for the development of new effective therapeutics. Altogether, the critical investigation of neurodegeneration-related proteins, their pathology, and other responsible factors as well as the study of new therapeutic possibilities can open new opportunities for future studies.
This Special Issue welcomes original research work (in vitro or in vivo), reviews, and clinical and case studies emphasizing mechanistic disease formation and progression, early diagnostic hallmarks, and new therapeutic approaches. This Special Issue aims to focus on the recent innovations in the field of different neurodegenerative disease biomarkers, therapeutic advancements, and combining the present approaches in the best possible way to improve the patients’ quality of life.
Dr. Sarmistha Mitra
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- neurodegenerative diseases
- ageing
- neurodegeneration hallmarks
- protein misfolding and aggregates
- molecular diagnosis
- therapeutic management
- small molecule and drug design
- complementary and alternative medicine
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
