Extracellular Vesicles in Regenerative Medicine

A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 3486

Special Issue Editor


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Guest Editor
1. McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
2. Department of Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA
Interests: regenerative medicine; extracellular matrix; bioscaffolds; tissue remodeling
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Special Issue Information

Dear Colleagues,

I invite you to contribute to a Special Issue of the journal Applied Sciences, entitled “Extracellular Vesicles for Regenerative Medicine”, which aims to present recent developments in the use of Extracellular Vesicles to promote healing and constructive tissue remodeling in regenerative medicine applications.

Extracellular vesicle (EV) is a generic, collective term for particles naturally released from the cell that are delimited by a lipid bilayer and cannot replicate. The term covers a range of subtypes, including exosomes, microvesicles, microparticles, ectosomes, oncosomes, apoptotic bodies, and matrix-bound nanovesicles. The increasing number of EV publications suggests a widespread interest in EV and their importance in numerous physiological pathways including cancer, inflammatory and autoimmune disease, wound healing, and tissue repair.

While consensus has not yet been reached on specific markers to define EV subtypes, the fact that EVs protect a luminal cargo of signaling molecules, including proteins, signaling lipids, cytokines, and miRNA, suggests they are important mediators of intercellular communication. For regenerative medicine, the ubiquitous nature of EVs has stimulated research into their biologic function and potential theranostic applications.

The potential for EV subtypes to reverse disease processes is becoming well established; however, multiple variables, including species, source material, harvesting method, and characterization and quantification methods, still need to be addressed if the theranostic potential of EVs is to be realized. I cordially invite you to submit your research on topics related to EVs in the form of original research papers, mini-reviews, and perspective articles.

Dr. Neill Turner
Guest Editor

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Keywords

  • Extracellular vesicle
  • Exosome
  • Matrix vesicle
  • Microparticles
  • Microvesicles
  • Nanovesicle
  • Tissue remodeling
  • Wound Healing
  • Tissue engineering
  • Regenerative medicine

Published Papers (1 paper)

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Review

18 pages, 851 KiB  
Review
Extracellular Vesicles for Regenerative Medicine Applications
by Raphael J. Crum, Héctor Capella-Monsonís, Stephen F. Badylak and George S. Hussey
Appl. Sci. 2022, 12(15), 7472; https://doi.org/10.3390/app12157472 - 25 Jul 2022
Cited by 7 | Viewed by 2914
Abstract
Tissue engineering and regenerative medicine (TERM) may be defined as a translational discipline focused on the development of novel techniques, devices, and materials to replace or repair injured or diseased tissue and organs. The main approaches typically use cells, scaffolds, and signaling molecules, [...] Read more.
Tissue engineering and regenerative medicine (TERM) may be defined as a translational discipline focused on the development of novel techniques, devices, and materials to replace or repair injured or diseased tissue and organs. The main approaches typically use cells, scaffolds, and signaling molecules, either alone or in combination, to promote repair and regeneration. Although cells are required to create new functional tissue, the source of cells, either from an exogenous allogeneic or autologous source or through the recruitment of endogenous (autologous) cells, is technically challenging and risks the host rejection of new tissue. Regardless of the cell source, these approaches also require appropriate instruction for proliferation, differentiation, and in vivo spatial organization to create new functional tissue. Such instruction is supplied through the microenvironment where cells reside, environments which largely consist of the extracellular matrix (ECM). The specific components of the ECM, and broadly the extracellular space, responsible for promoting tissue regeneration and repair, are not fully understood, however extracellular vesicles (EVs) found in body fluids and solid phases of ECM have emerged as key mediators of tissue regeneration and repair. Additionally, these EVs might serve as potential cell-free tools in TERM to promote tissue repair and regeneration with minimal risk for host rejection and adverse sequelae. The past two decades have shown a substantial interest in understanding the therapeutic role of EVs and their applications in the context of TERM. Therefore, the purpose of this review is to highlight the fundamental characteristics of EVs, the current pre-clinical and clinical applications of EVs in TERM, and the future of EV-based strategies in TERM. Full article
(This article belongs to the Special Issue Extracellular Vesicles in Regenerative Medicine)
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