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Applied Biosciences
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Experimental Biology: From Methods to Applications. Under the Auspices of...
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Experimental Biology: From Methods to Applications. Under the Auspices of the Italian Society of Experimental Biology, SIBS-1925

A special issue of Applied Biosciences (ISSN 2813-0464).

Deadline for manuscript submissions: 31 August 2025 | Viewed by 2659

Special Issue Editors

Prof. Dr. Francesco Cappello

E-Mail Website
Guest Editor
Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University of Palermo, 90127 Palermo, Italy
Interests: cell differentiation; tissue homeostasis; organ remodeling; cell stress; chaperones; heat shock proteins; chaperonopathies; exosomes
Special Issues, Collections and Topics in MDPI journals
Dr. Maria Grazia Palmerini

E-Mail Website
Guest Editor
Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy
Interests: reproduction; infertility; assisted reproductive technology; cryopreservation; environmental pollutants; oocyte; ovarian follicles; spermatozoa; embryos; histology; electron microscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Experimental biology aims to better understand natural phenomena via experiments and tests in laboratories to prove or disprove the hypotheses.

With this Special Issue, we want to invite researchers to submit their outstanding work in all the fields of experimental biology, such as  advanced microscopy and imaging, aging, human biology and anthropology, applied biochemistry, aquatic environments, artificial intelligence applied to biomedicine, biodiversity and modeling, reproduction and infertility, biomedical and pharmaceutical biotechnology, cellular stress, environment and health, micro- and nanovesicles in biomedicine, morphology, neuroscience, nutrition and food supplements, plant biology, precision medicine, regenerative medicine, structural biology, urban biodiversity, and other related topics.

This Special Issue has the auspicies of the Italian Society of Experimental Biology, SIBS-1925, which, in 2025, is going to celebrate its first centenary of scientific activities.

Prof. Dr. Francesco Cappello
Dr. Maria Grazia Palmerini
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Applied Biosciences is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • aging
  • anthropology
  • biochemistry
  • biodiversity
  • biomedicine
  • cellular stress
  • extracellular vesicles
  • marine biology
  • morphology
  • neuroscience
  • nutrition
  • precision medicine
  • regenerative medicine
  • reproduction and infertility
  • structural biology

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Further information on MDPI's Special Issue polices can be found here.

Published Papers (2 papers)

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16 pages, 2567 KiB  
Article
Into the Groove: A Multitechnique Insight into the DNA–Vemurafenib Interaction
by Gabriele Cavalieri, Riccardo Pison, Domenico Marson, Erik Laurini and Sabrina Pricl
Appl. Biosci. 2024, 3(4), 468-483; https://doi.org/10.3390/applbiosci3040030 - 21 Oct 2024
Viewed by 654
Abstract
This study explores the interaction between Vemurafenib (VEM), a potent BRAF inhibitor, and calf thymus DNA (ctDNA) using a comprehensive array of biophysical and computational techniques. The primary objective is to understand the potential off-target effects of VEM on DNA, given its established [...] Read more.
This study explores the interaction between Vemurafenib (VEM), a potent BRAF inhibitor, and calf thymus DNA (ctDNA) using a comprehensive array of biophysical and computational techniques. The primary objective is to understand the potential off-target effects of VEM on DNA, given its established role in melanoma therapy targeting the BRAF V600E mutation. The investigation employed methods such as ultraviolet–visible absorption spectroscopy, steady-state fluorescence, circular dichroism, isothermal titration calorimetry, and advanced molecular dynamics simulations. The results indicate that VEM interacts with DNA primarily through a minor groove-binding mechanism, causing minimal structural disruption to the DNA double helix. Viscosity measurements and melting temperature analyses further confirmed this non-intercalative mode of binding. Calorimetry data revealed an exothermic, thermodynamically favorable interaction between VEM and ctDNA, driven by both enthalpic and entropic factors. Finally, computer simulations identified the most probable binding site and mode of VEM within the minor groove of the nucleic acid, providing a molecular basis for the experimental findings. Full article
(This article belongs to the Special Issue Experimental Biology: From Methods to Applications. Under the Auspices of the Italian Society of Experimental Biology, SIBS-1925)
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13 pages, 2858 KiB  
Article
Deciphering the Role of the Nucleus Accumbens Shell Area on Spatial Memory Deficits Induced by Neuropathic Pain in Rats
by Mariana Cerqueira-Nunes, Clara Monteiro, Vasco Galhardo and Helder Cardoso-Cruz
Appl. Biosci. 2024, 3(2), 283-295; https://doi.org/10.3390/applbiosci3020019 - 12 Jun 2024
Viewed by 1196
Abstract
The nucleus accumbens shell (NAcSh) is a major structure associated with distinct aspects of reward and mnemonic information encoding, relying on spatial data to define optimal behavioral strategies. Chronic pain-derived striatal plasticity is considered one underpinning cause of working memory (WM) impairments. However, [...] Read more.
The nucleus accumbens shell (NAcSh) is a major structure associated with distinct aspects of reward and mnemonic information encoding, relying on spatial data to define optimal behavioral strategies. Chronic pain-derived striatal plasticity is considered one underpinning cause of working memory (WM) impairments. However, it is unclear how the NAcSh is involved in these spatial deficits. To address this, we evaluated the impact of unilateral local NAcSh electrical lesions during the execution of a food-reinforced eight-shaped spatial alternation WM task. Behavioral performance was assessed in rats after the onset of the neuropathic pain model—spared nerve injury (SNI). Our findings indicate that the induction of SNI and/or NAcSh lesions did not significantly impact the animals’ performance accuracy or motor activity during the execution of the behavioral task, but altered their response latency patterns. In addition, these manipulations did not induce significant antinociceptive effects. Collectively, these results suggest that the NAcSh may participate in specific aspects of spatial information integration and processing under neuropathic pain conditions. Full article
(This article belongs to the Special Issue Experimental Biology: From Methods to Applications. Under the Auspices of the Italian Society of Experimental Biology, SIBS-1925)
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