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Antioxidant Activity of Plant Phenolics, 2nd Edition

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 1789

Special Issue Editors

Department of Biochemistry and Biotechnology, University of Thessaly, Volos, Greece
Interests: polyphenols; antioxidants; redox status; toxicology; free radicals
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This is Series II of the Special Issue “Antioxidant Activity of Plant Phenolics”.

The demand for medicinal plants and their bioactive components has attained a commanding role in global health. The World Health Organization has reported that most of the Earth’s population relies on traditional medicine for their primary healthcare needs, rendering plants and their phytochemical components a main part of any investigation. The use of phytochemical components has been extensively proposed for the amelioration of several oxidative modifications since they possess potent antioxidant properties. The antioxidant properties of plant foods are mainly attributed to polyphenols, a large group of secondary metabolites acting as free radical scavengers and metal chelators and affecting the activity of antioxidant enzymes. The consumption of plant products is of great importance in the Mediterranean diet, known for its benefits to human health. Moreover, the determination of bioactive compounds responsible for pharmacological activities is critically important to producing proper and acceptable medicines. Several methodologies have been developed to evaluate the antioxidant capacity of crude natural extracts or pure isolated chemical compounds derived from natural sources. In this Special Issue, we invite researchers to contribute original research articles and review papers that will approach the complex nature of plant phenolics and assess their antioxidant activity using several methods in order to be introduced in follow-up studies.

Prof. Dr. Dimitrios Kouretas
Dr. Zoi Skaperda
Guest Editors

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Keywords

  • antioxidants
  • plants
  • phytochemical compounds
  • polyphenols
  • oxidative stress
  • natural products
  • bioactive compounds
  • herbs
  • biomarkers

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Published Papers (1 paper)

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Research

18 pages, 3540 KiB  
Article
Extraction Optimization of Phenolic Compounds from Triadica sebifera Leaves: Identification, Characterization and Antioxidant Activity
by Shao-Jun Fan, Xin-Yue Zhang, Yu Cheng, Yu-Xian Qiu, Yun-Yi Hu, Ting Yu, Wen-Zhang Qian, Dan-Ju Zhang and Shun Gao
Molecules 2024, 29(14), 3266; https://doi.org/10.3390/molecules29143266 - 10 Jul 2024
Cited by 1 | Viewed by 1350
Abstract
Triadica sebifera (T. sebifera) has attracted much attention because of the high oil content in its seeds, but there are few systematic studies on the phenolic compounds of T. sebifera leaves (TSP). In this study, the extraction process of TSP was [...] Read more.
Triadica sebifera (T. sebifera) has attracted much attention because of the high oil content in its seeds, but there are few systematic studies on the phenolic compounds of T. sebifera leaves (TSP). In this study, the extraction process of TSP was optimized by response surface methodology. The phenolic components of these extracts were analyzed by high-performance liquid chromatography (HPLC). Moreover, the effects of hot air drying (HD), vacuum drying (VD) and freeze drying (FD) on the antioxidant activity and characterization of T. sebifera leaf extract (TSLE) were evaluated. Under the conditions of ethanol concentration 39.8%, liquid–solid ratio (LSR) 52.1, extraction time 20.2 min and extraction temperature 50.6 °C, the maximum TSP yield was 111.46 mg GAE/g dw. The quantitative analysis and correlation analysis of eight compounds in TSP showed that the type and content of phenolic compounds had significant correlations with antioxidant activity, indicating that tannic acid, isoquercitrin and ellagic acid were the main components of antioxidant activities. In addition, through DPPH and ABTS determination, VD-TSLE and FD-TSLE showed strong scavenging ability, with IC50 values of 138.2 μg/mL and 135.5 μg/mL and 73.5 μg/mL and 74.3 μg/mL, respectively. Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) infrared spectroscopy revealed small differences in the extracts of the three drying methods. This study lays a foundation for the effective extraction process and drying methods of phenolic antioxidants from T. sebifera leaves, and is of great significance for the utilization of T. sebifera leaves. Full article
(This article belongs to the Special Issue Antioxidant Activity of Plant Phenolics, 2nd Edition)
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