Free Radicals, Oxidative Stress, and Antioxidants: Impact on Human Health
A special issue of Applied Sciences (ISSN 2076-3417). This special issue belongs to the section "Applied Biosciences and Bioengineering".
Deadline for manuscript submissions: 20 January 2026 | Viewed by 30
Special Issue Editor
Interests: molecular hydrogen; inflammation; oxidative stress; antioxidant; alkaline ionized water
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oxidative stress arises from an imbalance between reactive oxygen species (ROS) production and the body's antioxidant defense systems, leading to cellular and molecular damage. Excess ROS contribute to lipid peroxidation, protein oxidation, and DNA damage, triggering inflammatory responses and mitochondrial dysfunction. This oxidative burden is implicated in the pathogenesis of various chronic diseases, including neurodegenerative disorders, cardiovascular diseases, cancer, diabetes, and autoimmune conditions. Understanding the mechanisms by which free radicals drive disease progression is essential for developing effective therapeutic interventions.
Antioxidants, both enzymatic (e.g., superoxide dismutase, catalase, glutathione peroxidase) and non-enzymatic (e.g., vitamins C and E, polyphenols, flavonoids), play a crucial role in neutralizing ROS and maintaining redox homeostasis. Numerous studies highlight the potential of antioxidant-based therapies, redox-modulating compounds, and dietary interventions in mitigating oxidative stress-related damage. This Special Issue welcomes original research and review articles that explore oxidative stress mechanisms, novel antioxidant strategies, redox-targeted therapeutics, and clinical applications. We encourage the submission of papers utilizing advanced methodologies, including omics technologies, bioinformatics, and translational research models. This Special Issue aims to foster the development of novel therapeutic strategies for oxidative stress-related diseases by advancing our understanding of oxidative stress and antioxidant defense systems.
Dr. Cheol-Su Kim
Guest Editor
Manuscript Submission Information
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Keywords
- oxidative stress
- free radicals
- antioxidants
- redox homeostasis
- ROS
- inflammation
- mitochondrial dysfunction
- lipid peroxidation
- redox signaling
- therapeutic interventions
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