Special Issue "Antioxidant and Cytoprotective Activity"
A special issue of Antioxidants (ISSN 2076-3921).
Deadline for manuscript submissions: closed (20 April 2020).
Interests: polyphenols; flavonolignans; Silybum marianum; flavonols; quercetin; rutin; isoquercitrin; metabolites; gut microbiota; biotransformation by enzymes and whole cells
Special Issues and Collections in MDPI journals
Numerous chronic diseases are associated with oxidative stress and therefore some natural and synthetic antioxidants are proposed for the prevention and treatment of such diseases. Cellular protection against oxidative and electrophile toxicities (chemoprevention) can be ensured by two types of small molecules: Redox active, short-living direct antioxidants and indirect antioxidants that could have anti- and prooxidant activity, activating the Keap1/Nrf2/ARE pathway, which results in transcriptional induction of cytoprotective proteins. The pathophysiology of oxidative stress in humans is complex: Individual protective systems cooperate in a complex functional interplay; cytoprotective proteins are involved in the synthesis and/or regeneration of direct antioxidants, which in turn are often required for the catalytic functions of cytoprotective proteins. Direct antioxidant therapy usually failing in clinical trials and recent studies mostly confirms the involvement of several cell signaling pathways in cell protection in oxidative-stress-related conditions. Further investigation into this subject will provide renewed insight into the implication of oxidative stress in chronic diseases.
This Special Issue welcomes original research papers or reviews that deal with cytoprotective activity of natural antioxidants and inducers of cytoprotective proteins from plants or microorganisms, but also (semi)synthetic molecules and especially pleiotropic agents with protective effects in, for example, carcinogenesis, cardiovascular diseases, chronic respiratory diseases, diabetes mellitus, neurodegenerative diseases, retinal damage, and others. Studies focusing on the molecular mechanism of action of cytoprotective agents are particularly welcome. Studies based on undefined mixtures, extracts, or “principles” will not be accepted for publication in this Issue.
Dr. Kateřina Valentová
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- chronic diseases
- cytoprotective proteins
- mechanism of action