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Journals
Antioxidants
Special Issues
Phenolic Antioxidants in Functional Foods and Nutraceuticals
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Phenolic Antioxidants in Functional Foods and Nutraceuticals

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Extraction and Industrial Applications of Antioxidants".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 969

Special Issue Editors

Dr. Diana Andreia Tavares Pinto

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Guest Editor
REQUIMTE/LAQV, Polytechnic of Porto—School of Engineering, Rua Dr. António Bernardino de Almeida, 4249-015 Porto, Portugal
Interests: antioxidants; valorization of food by-products; green extraction technologies; in-vitro cell assays; in-vivo models; ex-vivo assays; metabolomics; nutraceutical application
Special Issues, Collections and Topics in MDPI journals
Dr. Francisca Rodrigues

E-Mail Website
Guest Editor
REQUIMTE/LAQV, Superior Institute of Engineering of Porto, Rua Dr. António Bernardino de Almeida 431, 4200-072 Porto, Portugal
Interests: natural extracts; bioactive compounds; antioxidants; in vitro assays; in vivo cosmetic assays; pharmaceutics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent decades, growing consumer awareness of health and wellness has significantly influenced the development of functional foods and nutraceuticals that are enriched with phenolic antioxidants. These bioactive compounds, widely recognized for their potent antioxidant, anti-inflammatory, and antimicrobial properties, play a crucial role in combating oxidative stress and preventing lifestyle-related diseases. Phenolic antioxidants, derived from a variety of natural sources, offer great potential for enhancing human health when incorporated into daily diets.

The extraction and stabilization of phenolic compounds remain critical challenges for industry, requiring the implementation of efficient and eco-friendly technologies. Additionally, characterizing these antioxidants through advanced analytical techniques, such as HPLC, LC-MS, and NMR, is essential to understand their mechanisms of action and evaluate their efficacy and safety. Despite extensive research, there remains a significant interest in innovative studies exploring the bioactivity, bioavailability, and applications of phenolic antioxidants in food and nutraceutical industries.

This Special Issue aims to explore pioneering research on the extraction, characterization, and functional applications of phenolic antioxidants, with a special emphasis on their valorization for food and nutraceutical products. We look forward to receiving contributions focused on novel extraction methods, bioactivity assessments, and the incorporation of phenolic antioxidants into sustainable and health-promoting foods and nutraceutical products.

Dr. Diana Andreia Tavares Pinto
Dr. Francisca Rodrigues
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive compounds
  • agri-food byproducts
  • in vitro assays
  • in vivo studies
  • green extraction
  • biological activities
  • safety assessment
  • industrial application

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Published Papers (1 paper)

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Research

30 pages, 6956 KB  
Article
Hepatoprotective, Antioxidant, and Anti-Hyperlipidemic Effects of Kefir Milk in High-Fat Diet-Induced Obesity: Insights from Gas Chromatography-Mass Spectrometry Profiling, Molecular Docking of Kefiran, and Liver Function Restoration
by Imen Hammami, Sonia Ben Younes, Ridha Ben Ali, Fatma Arrari, Afef Nahdi, Michèle Véronique El May, Rym Baati, Eduardo Alberto López-Maldonado and Abada Mhamdi
Antioxidants 2025, 14(12), 1500; https://doi.org/10.3390/antiox14121500 - 14 Dec 2025
Viewed by 459
Abstract
The prevalence of chronic diseases, including obesity and related endocrine disorders, has risen significantly in recent decades. As a result, there has been growing interest in fermented foods with probiotic properties, such as kefir, which have potential health benefits. This study aimed to [...] Read more.
The prevalence of chronic diseases, including obesity and related endocrine disorders, has risen significantly in recent decades. As a result, there has been growing interest in fermented foods with probiotic properties, such as kefir, which have potential health benefits. This study aimed to evaluate the hepatoprotective and antioxidant effects of kefir milk (KM) in a high-fat diet (HFD)-induced obesity rat model, complemented by in silico molecular docking studies with antioxidant enzymes. Twenty-four adult rats were divided into four groups: control (1 mL/100 g bw semi-skimmed cow milk), KM (1 mL/100 g bw kefir milk), HFD (1 mL/100 g bw semi-skimmed cow milk + high-fat diet), and KM/HFD (1 mL/100 g bw kefir milk + high-fat diet). After 60 days of treatment, biochemical assays and histological examinations were performed to assess the effects on lipid profiles and organ health. Kefir milk demonstrated significant antioxidant activity, with increased total phenolic content and enhanced DPPH, ABTS, and FRAP radical scavenging activities compared to commercial milk. Furthermore, KM administration protected against liver metabolic disruptions (ALT, AST, and LDH) induced by the high-fat diet and reduced lipid peroxidation in liver and testis tissues. KM supplementation also increased the activity of key antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx). Additionally, KM improved the fatty acid composition and decreased the de novo lipogenesis (DNL) index, as well as enzyme activities (SCD and Elovl6) associated with the high-fat diet. Histological analysis of liver, pancreas, and heart tissues revealed that kefir milk attenuated structural damage caused by the high-fat diet, suggesting its protective role in oxidative stress regulation and organ function. These findings underscore the potential of kefir milk as a functional food for preventing metabolic disturbances and liver damage associated with obesity. Full article
(This article belongs to the Special Issue Phenolic Antioxidants in Functional Foods and Nutraceuticals)
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