Nanomaterials as Antimicrobial Agents for Biomedical Applications

A special issue of Antibiotics (ISSN 2079-6382). This special issue belongs to the section "Antimicrobial Materials and Surfaces".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 2560

Special Issue Editors


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Guest Editor
National Institute for Laser, Plasma and Radiation Physics, RO-077125 Magurele, Romania
Interests: thin films/coatings; laser deposition methods; organic/inorganic compounds for biomedical application; oxides thin films; hard coatings
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Special Issue Information

Dear Colleagues,

Amongst public health, policies to fight against the spreading of multidrug-resistant pathogens and prevent the microbial contamination of different surfaces represent high priorities.

In recent years, (nano)materials that exhibit intrinsic antimicrobial activity in addition to having additive or synergic effects with antibiotics or other antimicrobials have been increasingly investigated and applied in several important fields, such as biomedicine (medical devices, protection equipment, surgery tools, human implants, etc.), the food industry (packaging), and surface cleaning, to prevent bacterial attachment and biofilm development.

Due to the rapid progress in nanotechnologies and depending on an application’s nature, materials with an antimicrobial effect derived from a large diversity of combinations (organic–organic, inorganic–organic, etc.) can be processed by different synthesis methods as nanoparticulates or nanostructured coatings.

The aim of this Special Issue is to offer to specialized readers a collection of research studies with the newest and most interesting results regarding nanostructured coatings that exhibit antibacterial properties.

  • Antimicrobial resistance.
  • Microbial contamination.
  • Nanostructured coatings.
  • Biofilm inhibition.
  • Nanomaterials.

Dr. Gabriela Dorcioman
Dr. Valentina Grumezescu
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antibiotics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Research

20 pages, 6296 KiB  
Article
New Fe3O4-Based Coatings with Enhanced Anti-Biofilm Activity for Medical Devices
by Ioana Adelina Pirușcă, Paul Cătălin Balaure, Valentina Grumezescu, Stefan-Andrei Irimiciuc, Ovidiu-Cristian Oprea, Alexandra Cătălina Bîrcă, Bogdan Vasile, Alina Maria Holban, Ionela C. Voinea, Miruna S. Stan, Roxana Trușcă, Alexandru Mihai Grumezescu and George-Alexandru Croitoru
Antibiotics 2024, 13(7), 631; https://doi.org/10.3390/antibiotics13070631 - 7 Jul 2024
Viewed by 630
Abstract
With the increasing use of invasive, interventional, indwelling, and implanted medical devices, healthcare-associated infections caused by pathogenic biofilms have become a major cause of morbidity and mortality. Herein, we present the fabrication, characterization, and in vitro evaluation of biocompatibility and anti-biofilm properties of [...] Read more.
With the increasing use of invasive, interventional, indwelling, and implanted medical devices, healthcare-associated infections caused by pathogenic biofilms have become a major cause of morbidity and mortality. Herein, we present the fabrication, characterization, and in vitro evaluation of biocompatibility and anti-biofilm properties of new coatings based on Fe3O4 nanoparticles (NPs) loaded with usnic acid (UA) and ceftriaxone (CEF). Sodium lauryl sulfate (SLS) was employed as a stabilizer and modulator of the polarity, dispersibility, shape, and anti-biofilm properties of the magnetite nanoparticles. The resulting Fe3O4 functionalized NPs, namely Fe3O4@SLS, Fe3O4@SLS/UA, and Fe3O4@SLS/CEF, respectively, were prepared by co-precipitation method and fully characterized by XRD, TEM, SAED, SEM, FTIR, and TGA. They were further used to produce nanostructured coatings by matrix-assisted pulsed laser evaporation (MAPLE) technique. The biocompatibility of the coatings was assessed by measuring the cell viability, lactate dehydrogenase release, and nitric oxide level in the culture medium and by evaluating the actin cytoskeleton morphology of murine pre-osteoblasts. All prepared nanostructured coatings exhibited good biocompatibility. Biofilm growth inhibition ability was tested at 24 h and 48 h against Staphylococcus aureus and Pseudomonas aeruginosa as representative models for Gram-positive and Gram-negative bacteria. The coatings demonstrated good biocompatibility, promoting osteoblast adhesion, migration, and growth without significant impact on cell viability or morphology, highlighting their potential for developing safe and effective antibacterial surfaces. Full article
(This article belongs to the Special Issue Nanomaterials as Antimicrobial Agents for Biomedical Applications)
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18 pages, 3512 KiB  
Article
A High-Performance Antibacterial Nanostructured ZnO Microfluidic Device for Controlled Bacterial Lysis and DNA Release
by Yvonni Xesfyngi, Maria Georgoutsou-Spyridonos, Abinash Tripathy, Athanasios Milionis, Dimos Poulikakos, Dimitrios C. Mastellos and Angeliki Tserepi
Antibiotics 2023, 12(8), 1276; https://doi.org/10.3390/antibiotics12081276 - 2 Aug 2023
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Abstract
In this work, the antibacterial properties of nanostructured zinc oxide (ZnO) surfaces are explored by incorporating them as walls in a simple-to-fabricate microchannel device. Bacterial cell lysis is demonstrated and quantified in such a device, which functions due to the action of its [...] Read more.
In this work, the antibacterial properties of nanostructured zinc oxide (ZnO) surfaces are explored by incorporating them as walls in a simple-to-fabricate microchannel device. Bacterial cell lysis is demonstrated and quantified in such a device, which functions due to the action of its nanostructured ZnO surfaces in contact with the working fluid. To shed light on the mechanism responsible for lysis, E. coli bacteria were incubated in zinc and nanostructured ZnO substrates, as well as the here-investigated ZnO-based microfluidic devices. The unprecedented killing efficiency of E. coli in nanostructured ZnO microchannels, effective after a 15 min incubation, paves the way for the implementation of such microfluidic chips in the disinfection of bacteria-containing solutions. In addition, the DNA release was confirmed by off-chip PCR and UV absorption measurements. The results indicate that the present nanostructured ZnO-based microfluidic chip can, under light, achieve partial inactivation of the released bacterial DNA via reactive oxygen species-mediated oxidative damage. The present device concept can find broader applications in cases where the presence of DNA in a sample is not desirable. Furthermore, the present microchannel device enables, in the dark, efficient release of bacterial DNA for downstream genomic DNA analysis. The demonstrated potential of this antibacterial device for tailored dual functionality in light/dark conditions is the main novel contribution of the present work. Full article
(This article belongs to the Special Issue Nanomaterials as Antimicrobial Agents for Biomedical Applications)
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