Canine and Feline Cardiomyopathies—Current and Future Strategies for Diagnosis and Treatment

A special issue of Animals (ISSN 2076-2615). This special issue belongs to the section "Veterinary Clinical Studies".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 906

Special Issue Editor


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Guest Editor
College of Veterinary Medicine, North Carolina State University, 1060 William Moore Drive, Raleigh, NC 27606, USA
Interests: translational cardiology; cardiac genetics; pharmacogenomics; novel drug development; feline cardiomyopathies

Special Issue Information

Dear Colleagues,

This Special Issue will focus on canine and feline cardiomyopathies. Immense progress has shaped the way that canine and feline cardiomyopathies are understood, diagnosed, and treated. Entirely new classes of drug compounds, unique genetic origins of naturally occurring disease, and advanced imaging techniques have resulted in immense preclinical and clinical progress throughout the last decade. Original research and review manuscripts on topics related to the diagnosis and treatment of canine and/or feline cardiomyopathies and disease outcomes will be considered for publication. Work including but not limited to genetic discoveries, diagnostic strategies, and novel therapies will make up the key articles of this important collection. This Special Issue will represent a collection of up-to-date resources documenting the standard-of-care in diagnosis and therapy, as well as novel advances in the understanding of pathophysiology, diagnostic strategies, and future therapies. 

Prof. Dr. Joshua A. Stern
Guest Editor

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Keywords

  • translational
  • cardiology
  • cardiomyopathy
  • hypertrophic
  • dilated
  • arrhythmogenic
  • fibrosing
  • diagnostic
  • cardiac
  • genetics
  • pharmacology
  • sarcomere

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Published Papers (1 paper)

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Research

16 pages, 14873 KiB  
Article
The Pathological and Histopathological Findings in Cats with Clinically Recognised Hypertrophic Cardiomyopathy Are Related to the Severity of Clinical Signs and Disease Duration
by Izabela Janus-Ziółkowska, Joanna Bubak, Rafał Ciaputa, Małgorzata Kandefer-Gola and Agnieszka Noszczyk-Nowak
Animals 2025, 15(5), 703; https://doi.org/10.3390/ani15050703 - 27 Feb 2025
Viewed by 701
Abstract
Hypertrophic cardiomyopathy (HCM) is the most frequent type of cardiac disease in cats. Due to its high prevalence and risk of sudden and severe signs, the disease is an important topic of various research. Despite the focus on the clinical course of the [...] Read more.
Hypertrophic cardiomyopathy (HCM) is the most frequent type of cardiac disease in cats. Due to its high prevalence and risk of sudden and severe signs, the disease is an important topic of various research. Despite the focus on the clinical course of the disease, studies presenting the pathological and histopathological patterns are rare. The study was conducted as a retrospective analysis of feline patients subjected to postmortem examination in the Cardiopathology Unit due to a clinical diagnosis of hypertrophic cardiomyopathy based on echocardiographic examination and ACVIM guidelines. Thirty-four cats clinically diagnosed with HCM were enrolled in the study. During the postmortem examination, hearts were subjected to gross morphometric and histopathological evaluation. Our results show that the histopathological pattern in cats with clinically stated HCM is very diverse, affecting both ventricles and atria. The histopathological picture is more complex in animals diagnosed earlier and treated for a longer period. Moreover, it is generally unrelated to wall thickness, with only left ventricular fibrosis affecting the thickness of the left ventricular wall. In conclusion, further research combining clinical and pathological results is required to unambiguously determine the histopathological remodelling that takes place in the myocardium of cats with hypertrophic cardiomyopathy. Full article
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