Multidimensional Drivers of Plant–Pathogen Interactions: From Molecular Mechanisms to Ecosystem Dynamics

A special issue of Agronomy (ISSN 2073-4395). This special issue belongs to the section "Pest and Disease Management".

Deadline for manuscript submissions: closed (31 January 2026) | Viewed by 2634

Special Issue Editors

State Key Laboratory of Rice Biology and Breeding, China National Center for Rice Improvement, China National Rice Research Institute, Hangzhou 310006, China
Interests: rice blast; rice false smut; high temperature
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State Key Laboratory of Rice Biology and Breeding, China National Rice Research Institute, Hangzhou 311400, China
Interests: pathogenicity of rice fungal pathogens; development of potential anti-fungicides
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Council for Agricultural Research and Economics (CREA), Research Centre for Genomics and Bioinformatics, Via S. Protaso 302, 29017 Fiorenzuola d’Arda, PC, Italy
Interests: DNA-based traceability of plant and microbial species; mycotoxin monitoring; natural antimicrobials; transcriptome analysis of cereal–fungal pathogen interactions
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Special Issue Information

Dear Colleagues,

Plant–pathogen interactions are a complex and dynamic relationship that has long attracted scientific interest, especially because pathogens cause significant losses in agriculture and forestry. Traditionally, studies have focused on plant immunity, pathogen virulence, and the genetic basis of resistance. However, researchers are increasingly recognizing that environmental factors such as temperature, humidity, soil composition, and atmospheric changes profoundly affect these interactions. This Special Issue aims to explore the impact of diverse environmental factors on the molecular, biochemical, and ecological aspects of plant–pathogen interactions. It seeks to provide a comprehensive view of how abiotic factors, including temperature, humidity, soil properties, and CO₂ levels, affect pathogen development, plant immune responses, and disease progression. Furthermore, it will address how environmental variability contributes to the emergence of new disease patterns, offering insights into managing plant health in a changing world.

Recent research in this field has highlighted how even subtle shifts in environmental conditions can lead to significant changes in disease susceptibility and severity. Cutting-edge studies investigate the underlying mechanisms at play—such as how temperature fluctuations influence pathogen growth cycles, or how drought stress affects a plant's immune system. New technologies, including high-throughput sequencing, remote sensing, and advanced modelling, enable scientists to dissect these interactions at the molecular and ecosystem levels.

We are soliciting original research articles, reviews, and case studies that focus on the following:

  • The effects of specific environmental factors (e.g., temperature, precipitation, soil nutrients) on plant–pathogen interactions;
  • Mechanistic studies examining how plants and pathogens adapt to changing environments;
  • The influence of global climate change on pathogen distribution and disease incidence;
  • Field studies and experiments assessing how variable environmental conditions affect pathogen virulence and plant resilience;
  • Technological approaches (e.g., remote sensing, bioinformatics) for studying plant–pathogen interactions in varying environmental contexts;
  • Modelling and predictive studies on future plant disease trends under projected climate scenarios.

We encourage submissions from multiple disciplines, including plant pathology, molecular biology, ecology, and climate science, to ensure a holistic view of how environmental factors shape plant health in natural and agricultural settings.

Dr. Jiehua Qiu
Dr. Huangbin Shi
Dr. Caterina Morcia
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Agronomy is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plant–pathogen interactions
  • environmental factors
  • plant health
  • climate change

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Published Papers (2 papers)

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Research

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24 pages, 3862 KB  
Article
The Consociation of Sage and Grapevine Modifies Grape Leaf Metabolism and Reduces Downy Mildew Infection
by Monica Fittipaldi Broussard, Carlo Campana, Veronica Ferrari, Ilaria Ragnoli, Leilei Zhang, Luigi Lucini, Vittorio Rossi, Tito Caffi and Giorgia Fedele
Agronomy 2026, 16(2), 201; https://doi.org/10.3390/agronomy16020201 - 14 Jan 2026
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Abstract
Volatile organic compounds (VOCs) produced by Medicinal Aromatic Plants (MAPs) are bioactive signaling molecules that play key roles in plant defense, acting against pathogens and triggering resistance responses. Intercropping with VOC-emitting MAPs can therefore enhance disease resistance. This study investigated VOCs emitted by [...] Read more.
Volatile organic compounds (VOCs) produced by Medicinal Aromatic Plants (MAPs) are bioactive signaling molecules that play key roles in plant defense, acting against pathogens and triggering resistance responses. Intercropping with VOC-emitting MAPs can therefore enhance disease resistance. This study investigated VOCs emitted by sage (Salvia officinalis) as potential resistance inducers in grapevine (Vitis vinifera) against Plasmopara viticola, the causal agent of downy mildew, under consociated growth conditions. Sage and grapevine plants were co-grown in an airtight box system for 24 or 48 h, after which grape leaves were inoculated with P. viticola. Disease assessments were integrated with grapevine leaf metabolic profiling to evaluate responses to VOC exposure and pathogen infection. Untargeted and targeted metabolomic analysis revealed that sage VOCs consistently reprogrammed grapevine secondary metabolism, without substantial differences between 24 and 48 h exposures. Lipids, phenylpropanoids, and terpenoids were markedly accumulated following VOC exposure and persisted following inoculation. Correspondingly, leaves pre-exposed to sage VOCs exhibited a significant reduction in disease susceptibility. Overall, our results suggest that exposure to sage VOCs induces signaling and metabolic reprogramming in grapevine. Further research should elucidate how grapevines perceive and integrate these signals, as well as the broader processes underlying MAP VOC-induced defense, and evaluate their translation into sustainable viticultural practices. Full article
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Review

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34 pages, 1084 KB  
Review
Cereal Health Regulation by Arbuscular Mycorrhizal Fungi (AMF): Insights from Tripartite Plant–AMF–Pathogen Systems Within the One Health Framework
by Maria Alexandra Cucu, Valeria Terzi, Alessandra Salvioli di Fossalunga, Paola Carnevali, Roberta Ghizzoni and Caterina Morcia
Agronomy 2026, 16(6), 621; https://doi.org/10.3390/agronomy16060621 - 14 Mar 2026
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Abstract
Tripartite interaction among arbuscular mycorrhizal fungi (AMF), small grain cereals—including wheat, barley, oats, and rye—and pathogenic organisms constitute a highly complex ecological system with major implications for plant health, productivity and resilience. AMF colonization increases nutrient acquisition, particularly phosphorus and nitrogen, while concurrently [...] Read more.
Tripartite interaction among arbuscular mycorrhizal fungi (AMF), small grain cereals—including wheat, barley, oats, and rye—and pathogenic organisms constitute a highly complex ecological system with major implications for plant health, productivity and resilience. AMF colonization increases nutrient acquisition, particularly phosphorus and nitrogen, while concurrently priming host defense mechanisms that increase resistance to a broad spectrum of pathogens. These benefits, however, are strongly context-dependent and modulated by AMF species composition, host genotype, soil characteristics, and environmental conditions. AMF activate resistance pathways and modulate the rhizosphere microbiome, underscoring their central role in shaping plant–pathogen dynamics. Importantly, the relevance of these interactions extend beyond crop protection and yield stability to encompass food security and sustainability goals aligned with the One Health framework, which recognizes the interconnectedness of plant, environmental, and human health. Field implementation of AMF-based strategies has the potential to reduce reliance on chemical fertilizers and pesticides, thereby promoting sustainable cereal production, restoring soil biodiversity, and enhancing ecosystem services, with downstream benefits for human nutrition and environmental safety. This review integrates current knowledge on AMF–cereal–pathogen interactions, synthesizing mechanistic advances and applied perspectives while identifying critical knowledge gaps that must be addressed to effectively deploy AMF in resilient and sustainable agroecosystems within a One Health context. Full article
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