Next Article in Journal
Study of Cytotoxicity and Internalization of Redox-Responsive Iron Oxide Nanoparticles on PC-3 and 4T1 Cancer Cell Lines
Next Article in Special Issue
Celecoxib Nanoformulations with Enhanced Solubility, Dissolution Rate, and Oral Bioavailability: Experimental Approaches over In Vitro/In Vivo Evaluation
Previous Article in Journal
Stability and Antibiotic Potency Improvement of Levofloxacin by Producing New Salts with 2,6- and 3,5-Dihydroxybenzoic Acid and Their Comprehensive Structural Study
Previous Article in Special Issue
Regularities of Encapsulation of Tolfenamic Acid and Some Other Non-Steroidal Anti-Inflammatory Drugs in Metal-Organic Framework Based on γ-Cyclodextrin
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Pharmaceutics
Volume 15
Issue 1
10.3390/pharmaceutics15010125
pharmaceutics-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Diammonium Glycyrrhizinate-Based Micelles for Improving the Hepatoprotective Effect of Baicalin: Characterization and Biopharmaceutical Study

by
Xingxing Dai
1,2,†,
Yuyao Liao
1,†,
Cuiting Yang
3,
Yingying Zhang
3,
Minfang Feng
1,
Yuting Tian
1,
Qingsong Qu
1,
Mengke Sheng
1,
Zhixun Li
1,
Xinhui Peng
1,
Shuai Cen
1 and
Xinyuan Shi
1,2,*
1
School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China
2
Key Laboratory for Production Process Control and Quality Evaluation of Traditional Chinese Medicine, Beijing Municipal Science & Technology Commission, Beijing 102488, China
3
School of Life Sciences, Beijing University of Chinese Medicine, Beijing 102488, China
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Pharmaceutics 2023, 15(1), 125; https://doi.org/10.3390/pharmaceutics15010125
Submission received: 1 November 2022 / Revised: 16 December 2022 / Accepted: 26 December 2022 / Published: 30 December 2022
(This article belongs to the Special Issue Design of Dosage Forms with Improved Biopharmaceutical Properties)
Browse Figures
Versions Notes

Abstract

Saponins are an important class of surface-active substances. When formulated as an active ingredient or co-used with other drugs, the effect of their surface activity on efficacy or safety must be considered. In this paper, diammonium glycyrrhizinate (DG), a clinical hepatoprotective drug that has long been used as a biosurfactant, was taken as the research object to study its combined hepatoprotective effect with baicalin (BAI). Animal experiments proved that the preparation of DG and BAI integrated into micelles (BAI-DG Ms) had a better protective effect on acute liver injury caused by carbon tetrachloride than the direct combined use of the two. From the perspective of biopharmaceutics, the synergistic mechanism of BAI-DG Ms was further explored. The results showed that after forming BAI-DG Ms with DG, the solubility of BAI increased by 4.75 to 6.25 times, and the cumulative percentage release in the gastrointestinal tract also increased by 2.42 times. In addition, the negatively charged BAI-DG Ms were more likely to penetrate the mucus layer and be absorbed by endocytosis. These findings provide support for the rational application of glycyrrhizin, and other saponins.
Keywords: surface-active drug; saponin; glycyrrhizic acid; biopharmaceutics; drug-loaded micelles surface-active drug; saponin; glycyrrhizic acid; biopharmaceutics; drug-loaded micelles
Graphical Abstract

Share and Cite

MDPI and ACS Style

Dai, X.; Liao, Y.; Yang, C.; Zhang, Y.; Feng, M.; Tian, Y.; Qu, Q.; Sheng, M.; Li, Z.; Peng, X.; et al. Diammonium Glycyrrhizinate-Based Micelles for Improving the Hepatoprotective Effect of Baicalin: Characterization and Biopharmaceutical Study. Pharmaceutics 2023, 15, 125. https://doi.org/10.3390/pharmaceutics15010125

AMA Style

Dai X, Liao Y, Yang C, Zhang Y, Feng M, Tian Y, Qu Q, Sheng M, Li Z, Peng X, et al. Diammonium Glycyrrhizinate-Based Micelles for Improving the Hepatoprotective Effect of Baicalin: Characterization and Biopharmaceutical Study. Pharmaceutics. 2023; 15(1):125. https://doi.org/10.3390/pharmaceutics15010125

Chicago/Turabian Style

Dai, Xingxing, Yuyao Liao, Cuiting Yang, Yingying Zhang, Minfang Feng, Yuting Tian, Qingsong Qu, Mengke Sheng, Zhixun Li, Xinhui Peng, and et al. 2023. "Diammonium Glycyrrhizinate-Based Micelles for Improving the Hepatoprotective Effect of Baicalin: Characterization and Biopharmaceutical Study" Pharmaceutics 15, no. 1: 125. https://doi.org/10.3390/pharmaceutics15010125

APA Style

Dai, X., Liao, Y., Yang, C., Zhang, Y., Feng, M., Tian, Y., Qu, Q., Sheng, M., Li, Z., Peng, X., Cen, S., & Shi, X. (2023). Diammonium Glycyrrhizinate-Based Micelles for Improving the Hepatoprotective Effect of Baicalin: Characterization and Biopharmaceutical Study. Pharmaceutics, 15(1), 125. https://doi.org/10.3390/pharmaceutics15010125

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop