21 December 2023
Cells | Top Cited Papers in 2022

“Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs”

by Aleksandra Twarda-Clapa, Aleksandra Twarda-Clapa, Aneta M. Białkowska and Maria Koziołkiewicz

Cells 2022, 11(8), 1312; https://doi.org/10.3390/cells11081312

Available online: https://www.mdpi.com/2073-4409/11/8/1312

“Multifactorial Mechanism of Sarcopenia and Sarcopenic Obesity. Role of Physical Exercise, Microbiota and Myokines”

by Jan Bilski, Piotr Pierzchalski, Marian Szczepanik, Joanna Bonior and Jerzy A. Zoladz

Cells 2022, 11(1), 160; https://doi.org/10.3390/cells11010160

Available online: https://www.mdpi.com/2073-4409/11/1/160

“Innate Immune Cell Death in Neuroinflammation and Alzheimer’s Disease”

by Yetirajam Rajesh and Thirumala-Devi Kanneganti

Cells 2022, 11(12), 1885; https://doi.org/10.3390/cells11121885

Available online: https://www.mdpi.com/2073-4409/11/12/1885

Protective Effects of Curcumin in Cardiovascular Diseases—Impact on Oxidative Stress and Mitochondria

by Fiona Frederike Cox, Angelina Misiou, Annika Vierkant, Niloofar Ale-Agha, Maria Grandoch, Judith Haendeler and Joachim Altschmied

Cells 2022, 11(3), 342; https://doi.org/10.3390/cells11030342

Available online: https://www.mdpi.com/2073-4409/11/3/342

Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration: A Review

by Takashi Ohnishi, Norimasa Iwasaki and Hideki Sudo

Cells 2022, 11(3), 394; https://doi.org/10.3390/cells11030394

Available online: https://www.mdpi.com/2073-4409/11/3/394

Into the Tissues: Extracellular Matrix and Its Artificial Substitutes: Cell Signalling Mechanisms

by Aleksandra Bandzerewicz and Agnieszka Gadomska-Gajadhur

Cells 2022, 11(5), 914; https://doi.org/10.3390/cells11050914

Available online: https://www.mdpi.com/2073-4409/11/5/914

The Role of the Immune System in the Development of Endometriosis

by Monika Abramiuk, Ewelina Grywalska, Paulina Małkowska, Olga Sierawska, Rafał Hrynkiewicz and Niedźwiedzka-Rystwej

Cells 2022, 11(13), 2028; https://doi.org/10.3390/cells11132028

Available online: https://www.mdpi.com/2073-4409/11/13/2028

Stem Cells and Angiogenesis: Implications and Limitations in Enhancing Chronic Diabetic Foot Ulcer Healing

by Vikrant Rai, Rebecca Moellmer and Devendra K. Agrawal

Cells 2022, 11(15), 2287; https://doi.org/10.3390/cells11152287

Available online: https://www.mdpi.com/2073-4409/11/15/2287

Cardiovascular Inflammaging: Mechanisms and Translational Aspects

by Maria Luisa Barcena, Muhammad Aslam, Sofya Pozdniakova, Kristina Norman and Yury Ladilov

Cells 2022, 11(6), 1010; https://doi.org/10.3390/cells11061010

Available online: https://www.mdpi.com/2073-4409/11/6/1010

One-Carbon Metabolism: Pulling the Strings behind Aging and Neurodegeneration

by Eirini Lionaki, Christina Ploumi and Nektarios Tavernarakis

Cells 2022, 11(2), 214; https://doi.org/10.3390/cells11020214

Available online: https://www.mdpi.com/2073-4409/11/2/214

Tendon Immune Regeneration: Insights on the Synergetic Role of Stem and Immune Cells during Tendon Regeneration

by Valentina Russo, Mohammad El Khatib, Giuseppe Prencipe, Maria Rita Citeroni, Melisa Faydaver, Annunziata Mauro, Paolo Berardinelli, Adrián Cerveró-Varona, Arlette A. Haidar-Montes, Maura Turriani et al.

Cells 2022, 11(3), 434; https://doi.org/10.3390/cells11030434

Available online: https://www.mdpi.com/2073-4409/11/3/434

Necroptosis and Prostate Cancer: Molecular Mechanisms and Therapeutic Potential

by Giovanni Luca Beretta and Nadia Zaffaroni

Cells 2022, 11(7), 1221; https://doi.org/10.3390/cells11071221

Available online: https://www.mdpi.com/2073-4409/11/7/1221

Extracellular Release of Mitochondrial DNA: Triggered by Cigarette Smoke and Detected in COPD

by Luca Giordano, Alyssa D. Gregory, Mireia Pérez Verdaguer, Sarah A. Ware, Hayley Harvey, Evan DeVallance, Tomasz Brzoska, Prithu Sundd, Yingze Zhang, Frank C. Sciurba et al.

Cells 2022, 11(3), 369; https://doi.org/10.3390/cells11030369

Available online: https://www.mdpi.com/2073-4409/11/3/369

“Glucose Regulates m6A Methylation of RNA in Pancreatic Islets”

by Florine Bornaque, Clément Philippe Delannoy, Emilie Courty, Nabil Rabhi, Charlène Carney, Laure Rolland, Maeva Moreno, Xavier Gromada, Cyril Bourouh, Pauline Petit et al.

Cells 2022, 11(2), 291; https://doi.org/10.3390/cells11020291

Available online: https://www.mdpi.com/2073-4409/11/2/291

“High-Fat Diet-Induced Dysregulation of Immune Cells Correlates with Macrophage Phenotypes and Chronic Inflammation in Adipose Tissue”

by Sonia Kiran, Ahmed Rakib, Sunitha Kodidela, Santosh Kumar and Udai P. Singh

Cells 2022, 11(8), 1327; https://doi.org/10.3390/cells11081327

Available online: https://www.mdpi.com/2073-4409/11/8/1327

“Anticoagulants: A Short History, Their Mechanism of Action, Pharmacology, and Indications”

by Marco Heestermans, Géraldine Poenou, Hind Hamzeh-Cognasse, Fabrice Cognasse and Laurent Bertoletti

Cells 2022, 11(20), 3214; https://doi.org/10.3390/cells11203214

Available online: https://www.mdpi.com/2073-4409/11/20/3214

“Probiotics in the Prevention of the Calcium Oxalate Urolithiasis”

by Paulina Wigner, Michał Bijak and Joanna Saluk-Bijak

Cells 2022, 11(2), 284; https://doi.org/10.3390/cells11020284

Available online: https://www.mdpi.com/2073-4409/11/2/284

“The Future of the COVID-19 Pandemic: How Good (or Bad) Can the SARS-CoV2 Spike Protein Get?”

by Matthew A. Nugent

Cells 2022, 11(5), 855; https://doi.org/10.3390/cells11050855

Available online: https://www.mdpi.com/2073-4409/11/5/855

“Dance of The Golgi: Understanding Golgi Dynamics in Cancer Metastasis”

by Rakhee Bajaj, Amanda N. Warner, Jared F. Fradette and Don L. Gibbons

Cells 2022, 11(9), 1484; https://doi.org/10.3390/cells11091484

Available online: https://www.mdpi.com/2073-4409/11/9/1484

Endothelial Progenitor Cells as Biomarkers of Cardiovascular Pathologies: A Narrative Review”

by Paul Philipp Heinisch, Corina Bello, Maximilian Y. Emmert, Thierry Carrel, Martina Dreßen, Jürgen Hörer, Bernhard Winkler and Markus M. Luedi

Cells 2022, 11(10), 1678; https://doi.org/10.3390/cells11101678

Available online: https://www.mdpi.com/2073-4409/11/10/1678

“Transient Exposure of Endothelial Cells to Doxorubicin Leads to Long-Lasting Vascular Endothelial Growth Factor Receptor 2 Downregulation”

by Silvia Graziani, Luca Scorrano and Giovanna Pontarin

Cells 2022, 11(2), 210; https://doi.org/10.3390/cells11020210

Available online: https://www.mdpi.com/2073-4409/11/2/210

Mesenchymal Stromal/Stem Cells and Their Products as a Therapeutic Tool to Advance Lung Transplantation”

by Vitale Miceli and Alessandro Bertani

Cells 2022, 11(5), 826; https://doi.org/10.3390/cells11050826

Available online: https://www.mdpi.com/2073-4409/11/5/826

Pyroptosis and Its Role in SARS-CoV-2 Infection”

by Zsofia Agnes Bittner, Markus Schrader, Shilpa Elizabeth George and Ralf Amann

Cells 2022, 11(10), 1717; https://doi.org/10.3390/cells11101717

Available online: https://www.mdpi.com/2073-4409/11/10/1717

The H+ Transporter SLC4A11: Roles in Metabolism, Oxidative Stress and Mitochondrial Uncoupling”

by Joseph A. Bonanno, Raji Shyam, Moonjung Choi and Diego G. Ogando

Cells 2022, 11(2), 197; https://doi.org/10.3390/cells11020197

Available online: https://www.mdpi.com/2073-4409/11/2/197

“Molecular Mechanisms of Exercise and Healthspan”

by Yuntian Guan and Zhen Yan

Cells 2022, 11(5), 872; https://doi.org/10.3390/cells11050872

Available online: https://www.mdpi.com/2073-4409/11/5/872

“Modulating the Ubiquitin–Proteasome System: A Therapeutic Strategy for Autoimmune Diseases”

by Dhananjay Yadav, Ji Yeon Lee, Nidhi Puranik, Pallavi S. Chauhan, Vishal Chavda, Jun-O. Jin and Peter C. W. Lee

Cells 2022, 11(7), 1093; https://doi.org/10.3390/cells11071093

Available online: https://www.mdpi.com/2073-4409/11/7/1093

Understanding Molecular Mechanisms of Phenotype Switching and Crosstalk with TME to Reveal New Vulnerabilities of Melanoma”

by Ahmad Najem, Laura Soumoy, Malak Sabbah, Mohammad Krayem, Ahmad Awada, Fabrice Journe and Ghanem E. Ghanem

Cells 2022, 11(7), 1157; https://doi.org/10.3390/cells11071157

Available online: https://www.mdpi.com/2073-4409/11/7/1157

Verteporfin Inhibits the Progression of Spontaneous Osteosarcoma Caused by Trp53 and Rb1 Deficiency in Ctsk-Expressing Cells via Impeding Hippo Pathway”

by Yang Li, Shuting Yang and Shuying Yang

Cells 2022, 11(8), 1361; https://doi.org/10.3390/cells11081361

Available online: https://www.mdpi.com/2073-4409/11/8/1361

Role of Intestinal Dysbiosis and Nutrition in Rheumatoid Arthritis”

by Malavikalakshmi Attur, Jose U Scher, Steven B. Abramson and Mukundan Attur

Cells 2022, 11(15), 2436; https://doi.org/10.3390/cells11152436

Available online: https://www.mdpi.com/2073-4409/11/15/2436

Apple Derived Exosomes Improve Collagen Type I Production and Decrease MMPs during Aging of the Skin through Downregulation of the NF-κB Pathway as Mode of Action”

by Martina Trentini, Ilaria Zanolla, Federica Zanotti, Elena Tiengo, Danilo Licastro, Simeone Dal Monego, Luca Lovatti and Barbara Zavan

Cells 2022, 11(24), 3950; https://doi.org/10.3390/cells11243950

Available online: https://www.mdpi.com/2073-4409/11/24/3950

“Regulation of Mitochondrial Hydrogen Peroxide Availability by Protein S-glutathionylation”

by Ryan J. Mailloux, Cathryn Grayson and Olivia Koufos

Cells 2023, 12(1), 107; https://doi.org/10.3390/cells12010107

Available online: https://www.mdpi.com/2073-4409/12/1/107

“Transcriptional Heterogeneity and the Microbiome of Cutaneous T-Cell Lymphoma”

by Philipp Licht and Volker Mailander

Cells 2022, 11(3), 328; https://doi.org/10.3390/cells11030328

Available online: https://www.mdpi.com/2073-4409/11/3/328

Cytochrome c Oxidase Inhibition by ATP Decreases Mitochondrial ROS Production”

by Rabia Ramzan, Amalia M. Dolga, Susanne Michels, Petra Weber, Carsten Culmsee, Ardawan J. Rastan and Sebastian Vogt

Cells 2022, 11(6), 992; https://doi.org/10.3390/cells11060992

Available online: https://www.mdpi.com/2073-4409/11/6/992

The Protective Action of Metformin against Pro-Inflammatory Cytokine-Induced Human Islet Cell Damage and the Mechanisms Involved”

by Laura Giusti, Marta Tesi, Federica Ciregia, Lorella Marselli, Lorenzo Zallocco, Mara Suleiman, Carmela De Luca, Silvia Del Guerra, Mariachiara Zuccarini, Marco Trerotola et al.

Cells 2022, 11(15), 2465; https://doi.org/10.3390/cells11152465

Available online: https://www.mdpi.com/2073-4409/11/15/2465

“Neurodegenerative Disease-Associated TDP-43 Fragments Are Extracellularly Secreted with CASA Complex Proteins”

Elena Casarotto, Daisy Sproviero, Eleonora Corridori, Maria Cristina Gagliani, Marta Cozzi, Marta Chierichetti, Riccardo Cristofani, Veronica Ferrari, Mariarita Galbiati, Francesco Mina et al.

Cells 2022, 11(3), 516; https://doi.org/10.3390/cells11030516

Available online: https://www.mdpi.com/2073-4409/11/3/516

The Cell Membrane of a Novel Rhizobium phaseoli Strain Is the Crucial Target for Aluminium Toxicity and Tolerance”

by Clabe Wekesa, John O. Muoma, Michael Reichelt, George O. Asudi, Alexandra C. U. Furch and Ralf Oelmüller

Cells 2022, 11(5), 873; https://doi.org/10.3390/cells11050873

Available online: https://www.mdpi.com/2073-4409/11/5/873

Senescence-Associated Cell Transition and Interaction (SACTAI): A Proposed Mechanism for Tissue Aging, Repair, and Degeneration”

by Yajun Liu, Jonah Schwam and Qian Chen

Cells 2022, 11(7), 1089; https://doi.org/10.3390/cells11071089

Available online: https://www.mdpi.com/2073-4409/11/7/1089

Mesenchymal Stromal Cell-Derived Extracellular Vesicles for Neonatal Lung Disease: Tiny Particles, Major Promise, Rigorous Requirements for Clinical Translation”

by Flore Lesage and Bernard Thébaud

Cells 2022, 11(7), 1176; https://doi.org/10.3390/cells11071176

Available online: https://www.mdpi.com/2073-4409/11/7/1176

The Cytoskeleton Effectors Rho-Kinase (ROCK) and Mammalian Diaphanous-Related (mDia) Formin Have Dynamic Roles in Tumor Microtube Formation in Invasive Glioblastoma Cells”

by Kathryn N. Becker, Krista M. Pettee, Amanda Sugrue, Kevin A. Reinard, Jason L. Schroeder and Kathryn M. Eisenmann

Cells 2022, 11(9), 1559; https://doi.org/10.3390/cells11091559

Available online: https://www.mdpi.com/2073-4409/11/9/1559

“Reactive Oxygen Species in Regulating Lymphangiogenesis and Lymphatic Function”

by Bhupesh Singla, Ravi Varma Aithabathula, Sonia Kiran, Shweta Kapil, Santosh Kumar and Udai P. Singh

Cells 2022, 11(11), 1750; https://doi.org/10.3390/cells11111750

Available online: https://www.mdpi.com/2073-4409/11/11/1750

“Mitochondrial Damage-Associated Molecular Patterns Content in Extracellular Vesicles Promotes Early Inflammation in Neurodegenerative Disorders”

by Cláudia M. Deus, Henrique Tavares, Margarida Beatriz, Sandra Mota and Carla Lopes

Cells 2022, 11(15), 2364; https://doi.org/10.3390/cells11152364

Available online: https://www.mdpi.com/2073-4409/11/15/2364

Akkermansia muciniphila Reduces Peritonitis and Improves Intestinal Tissue Wound Healing after a Colonic Transmural Defect by a MyD88-Dependent Mechanism”

by Radu Bachmann, Matthias Van Hul, Pamela Baldin, Daniel Léonard, Nathalie M. Delzenne, Clara Belzer, Janneke P. Ouwerkerk, Dirk Repsilber, Ignacio Rangel and Alex Kartheuser

Cells 2022, 11(17), 2666; https://doi.org/10.3390/cells11172666

Available online: https://www.mdpi.com/2073-4409/11/17/2666

STAT3 and Its Pathways’ Dysregulation—Underestimated Role in Urological Tumors“

by Maciej Golus, Piotr Bugajski, Joanna Chorbińska, Wojciech Krajewski, Artur Lemiński, Jolanta Saczko, Julita Kulbacka, Tomasz Szydełko and Bartosz Małkiewicz

Cells 2022, 11(19), 3024; https://doi.org/10.3390/cells11193024

Available online: https://www.mdpi.com/2073-4409/11/19/3024

Bone Marrow Mesenchymal Stromal/Stem Cell-Derived Extracellular Vesicles Promote Corneal Wound Repair by Regulating Inflammation and Angiogenesis”

by Gabriele Saccu, Valeria Menchise, Chiara Gai, Marina Bertolin, Stefano Ferrari, Cristina Giordano, Marta Manco, Walter Dastrù, Emanuela Tolosano and Benedetta Bussolati

Cells 2022, 11(23), 3892; https://doi.org/10.3390/cells11233892

Available online: https://www.mdpi.com/2073-4409/11/23/3892

Enhancing In Vitro Production of the Tree Fern Cyathea delgadii and Modifying Secondary Metabolite Profiles by LED Lighting”

by Wojciech Tomaszewicz, Monika Cioć, Katarzyna Dos Santos Szewczyk, Małgorzata Grzyb, Wioleta Pietrzak, Bożena Pawłowska and Anna Mikuła

Cells 2022, 11(3), 486; https://doi.org/10.3390/cells11030486

Available online: https://www.mdpi.com/2073-4409/11/3/486

C53 Interacting with UFM1-Protein Ligase 1 Regulates Microtubule Nucleation in Response to ER Stress”

by Anastasiya Klebanovych, Stanislav Vinopal, Eduarda Dráberová, Vladimíra Sládková, Tetyana Sulimenko, Vadym Sulimenko, Věra Vosecká, Libor Macůrek, Agustin Legido and Pavel Dráber

Cells 2022, 11(3), 555; https://doi.org/10.3390/cells11030555

Available online: https://www.mdpi.com/2073-4409/11/3/555

“Targeting Protein O-GlcNAcylation, a Link between Type 2 Diabetes Mellitus and Inflammatory Disease”

by Israel Olapeju Bolanle and Timothy M. Palmer

Cells 2022, 11(4), 705; https://doi.org/10.3390/cells11040705

Available online: https://www.mdpi.com/2073-4409/11/4/705

How Cargo Identity Alters the Uptake of Cell-Penetrating Peptide (CPP)/Cargo Complexes: A Study on the Effect of Net Cargo Charge and Length”

By Hannah C. Hymel, Alireza Rahnama, Olivia M. Sanchez, Dong Liu, Ted J. Gauthier and Adam T. Melvin

Cells 2022, 11(7), 1195; https://doi.org/10.3390/cells11071195

Available online: https://www.mdpi.com/2073-4409/11/7/1195

Human Platelet-Rich Plasma Facilitates Angiogenesis to Restore Impaired Uterine Environments with Asherman’s Syndrome for Embryo Implantation and Following Pregnancy in Mice”

by Min Kyoung Kim, Jung Ah Yoon, Sook Young Yoon, Mira Park, Woo Sik Lee, Sang Woo Lyu and Haengseok Song

Cells 2022, 11(9), 1549; https://doi.org/10.3390/cells11091549

Available online: https://www.mdpi.com/2073-4409/11/9/1549

“Targeting Acid Ceramidase Inhibits Glioblastoma Cell Migration through Decreased AKT Signaling”

by Cyntanna C. Hawkins, Amber B. Jones, Emily R. Gordon, Sarah E. Williford, Yuvika Harsh, Julia K. Ziebro, Catherine J. Landis, Sajina Gc, David K. Crossman and Sara J. Cooper

Cells 2022, 11(12), 1873; https://doi.org/10.3390/cells11121873

Available online: https://www.mdpi.com/2073-4409/11/12/1873

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