Next Article in Journal
Mucosal Mast Cells as Key Effector Cells in Food Allergies
Next Article in Special Issue
Sézary Syndrome: Different Erythroderma Morphological Features with Proposal for a Clinical Score System
Previous Article in Journal
Enhanced Loss of Retinoic Acid Network Genes in Xenopus laevis Achieves a Tighter Signal Regulation
Previous Article in Special Issue
Strategies to Optimize Adherence in Patients with Mycosis Fungoides
 
 
Review

Transcriptional Heterogeneity and the Microbiome of Cutaneous T-Cell Lymphoma

1
Dermatology Clinic, University Medical Center of the Johannes Gutenberg-University Mainz, Langenbeckstraße 1, 55131 Mainz, Germany
2
Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany
*
Author to whom correspondence should be addressed.
Academic Editors: Ivan V. Litvinov, Robert Gniadecki, Niels Ødum and Madeleine Duvic
Cells 2022, 11(3), 328; https://doi.org/10.3390/cells11030328
Received: 29 September 2021 / Revised: 31 December 2021 / Accepted: 13 January 2022 / Published: 19 January 2022
Cutaneous T-Cell Lymphomas (CTCL) presents with substantial clinical variability and transcriptional heterogeneity. In the recent years, several studies paved the way to elucidate aetiology and pathogenesis of CTCL using sequencing methods. Several T-cell subtypes were suggested as the source of disease thereby explaining clinical and transcriptional heterogeneity of CTCL entities. Several differentially expressed pathways could explain disease progression. However, exogenous triggers in the skin microenvironment also seem to affect CTCL status. Especially Staphylococcus aureus was shown to contribute to disease progression. Only little is known about the complex microbiome patterns involved in CTCL and how microbial shifts might impact this malignancy. Nevertheless, first hints indicate that the microbiome might at least in part explain transcriptional heterogeneity and that microbial approaches could serve in diagnosis and prognosis. Shaping the microbiome could be a treatment option to maintain stable disease. Here, we review current knowledge of transcriptional heterogeneity of and microbial influences on CTCL. We discuss potential benefits of microbial applications and microbial directed therapies to aid patients with CTCL burden. View Full-Text
Keywords: cutaneous T-cell lymphoma (CTCL); mycosis fungoides (MF); Sézary syndrome (SS); transcriptome; microbiome; heterogeneity cutaneous T-cell lymphoma (CTCL); mycosis fungoides (MF); Sézary syndrome (SS); transcriptome; microbiome; heterogeneity
Show Figures

Graphical abstract

MDPI and ACS Style

Licht, P.; Mailänder, V. Transcriptional Heterogeneity and the Microbiome of Cutaneous T-Cell Lymphoma. Cells 2022, 11, 328. https://doi.org/10.3390/cells11030328

AMA Style

Licht P, Mailänder V. Transcriptional Heterogeneity and the Microbiome of Cutaneous T-Cell Lymphoma. Cells. 2022; 11(3):328. https://doi.org/10.3390/cells11030328

Chicago/Turabian Style

Licht, Philipp, and Volker Mailänder. 2022. "Transcriptional Heterogeneity and the Microbiome of Cutaneous T-Cell Lymphoma" Cells 11, no. 3: 328. https://doi.org/10.3390/cells11030328

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop